Table 32-1. Effects of ergot alkaloids at several receptors. Ergot alkaloids Serotonin receptor α-Adrenoceptor Dopamin e receptor Uterine smooth muscle stimulation Clinical use Lysergide(LSD) + + in CNS 0++++ Ergometrine (PA) +++++Postpartum haemorrhage Methysergide (PA) +/0 Migraine Ergotamine+(PA) (PA) 0+++Migraine Bromocriptine +++0Parkinson’s disease Agonist effect is indicated by +, antagonist by , no effect by 0. The number of sign (+ or –) indicates relative affinity for the receptor. PA means partial agonist.
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