20 Figure 10. Histopathology of histoplasmosis in open lung biopsy. FA stain
21 Figure 5. Histopathology of blastomycosis, lung Figure 5. Histopathology of blastomycosis, lung
22 Porcine cDNA microarray Defining the response of macrophages to ASFV infection is critical to understanding mechanisms of virus pathogenesis and immune evasion逃避. We have developed a porcine cDNA microarray containing 2500 genes which are of interest in defining host responses to infection. This microarray is being used to study changes in gene expression that occur in macrophages at different times post-infection with ASFV isolates of different virulence. We are also analysing the effects of individual ASFV immune evasion genes, such as A238L and CD2v, on patterns of host macrophage gene expression.