1 Jheng-Fong Jhong( 鍾政峰 ), Yung Chang ( 張雍 ), R&D Center for Membrane Technology and Department of Chemical Engineering, Chung Yuan University, Taiwan.

Presentation on theme: "1 Jheng-Fong Jhong( 鍾政峰 ), Yung Chang ( 張雍 ), R&D Center for Membrane Technology and Department of Chemical Engineering, Chung Yuan University, Taiwan."— Presentation transcript:

1 1 Jheng-Fong Jhong( 鍾政峰 ), Yung Chang ( 張雍 ), R&D Center for Membrane Technology and Department of Chemical Engineering, Chung Yuan University, Taiwan ( 中原大學薄膜技術研發中心 ) 2012/11/20 雙離子性氟素材於傷口癒合之應用開發

2 R&D Center for Membrane Technology 2 Jheng-Fong Jhong 雙離子性氟素材於傷口癒合之應用開發 General concept of wound healing

3 R&D Center for Membrane Technology 3 Jheng-Fong Jhong The performance of designed surfaces contact with human blood? Membranes used in human body General Surface Hemocompatible Control Designed Surface 雙離子性氟素材於傷口癒合之應用開發

4 R&D Center for Membrane Technology 4 Jheng-Fong Jhong Cell membrane polyether Oligo(ethylene glycol) (OEG)-based materials Poly(ethylene glycol) (PEG)-based materials Widely used: “Ideal anti-fouling candidates Bio-mimetic “Nature bioinert surface” General synthetic systems Sulfobetaine methacrylate (SBMA) 雙離子性氟素材於傷口癒合之應用開發

5 R&D Center for Membrane Technology 5 Jheng-Fong Jhong >< >< Ar Argon X-Y axis controller RF power generator March box Sample Plasma jet 150W Atmospheric Pressure Plasma Jet (APPJ) Plasma treatment Characterization  Without vacuum system  Time reduction  Low energy consumption Input power: 150 W Flow rate: 10 slm

6 R&D Center for Membrane Technology 6 Jheng-Fong Jhong 雙離子性氟素材於傷口癒合之應用開發 Ar + F FF Plasma induced surface modification

7 R&D Center for Membrane Technology 7 Jheng-Fong Jhong 雙離子性氟素材於傷口癒合之應用開發 Plasma induced surface modification + - Biomimetic Interface + - + - + -

8 R&D Center for Membrane Technology 8 Jheng-Fong Jhong 2.5cm 1cm 1.5cm SD rat Age 8~10 week (420g) 雙離子性氟素材於傷口癒合之應用開發 wound Animal wound healing test

9 R&D Center for Membrane Technology 9 Jheng-Fong Jhong 雙離子性氟素材於傷口癒合之應用開發 Platelet Bacterial RBC

10 R&D Center for Membrane Technology 10 Jheng-Fong Jhong 雙離子性氟素材於傷口癒合之應用開發

11 R&D Center for Membrane Technology 11 Jheng-Fong Jhong Acknowledgement We wish to express their sincere gratitude to The Center-of-Excellence (COE) Program on Membrane Technology from the Ministry of Education (MOE), R.O.C. The National Science Council for their financial support. C ENTER for M EMBRANE T ECHNOLOGY RESEARCH & DEVELOPMENT

12 R&D Center for Membrane Technology 12 Jheng-Fong Jhong THANK YOU FOR YOUR ATTENTION