The Cerebellum.

Presentation on theme: "The Cerebellum."— Presentation transcript:

1 The Cerebellum

2 Position Lies above and behind the medullar and pons and occupies posterior cranial fossa Cerebellum

3 External features Consists of two cerebellar hemisphere united in the midline by the vermis

4 External features Three peduncles
Inferior cerebellar peduncle －connect with medulla and with spinal cord, contain both afferent and efferent fibers Middle cerebellar peduncle －connect with pons, contain afferent fibers Superior cerebellar peduncle －connect with midbrain, contain mostly efferent fibers

5 External features Tonsil of cerebellum two elevated masses on inferior surface of hemispheral portion just nearby foramen magnum

6 Lobs Two deep fissures Three lobs Primary fissure
Posterolateral fissure Three lobs Flocculonodular lobe 叶 flocculus and nodule Anterior lobe Posterior lobe Corpus of cerebellar

7 Lobs Anterior lobe corpus of cerebellar Primary fissure Posterior lobe
Flocculonodular lobe Posterolateral fissure

8 Internal structures White matter－medullary center Gray matter
Cerebellar cortex Cerebellar nuclei Dentate nucleus Fastigial nucleus Interposed nucleus Emboliform nucleus Globose nucleus White matter－medullary center

9 Internal structures Fastigial nucleus Cerebellar cortex
Globose nucleus Dentate nucleus Emboliform nucleus medullary center

10 Three functional divisions
Vestibulocerebellum Archicerebellum Flocculonodular lobe Spinocerebellum Paleocerebellum Vermis and intermediate zone Cerebrocerebellum Neocerebellum Lateral zone Vermis Intermediate zone Lateral zone Flocculonodular lobe

11 Connections and function of cerebellum
Vestibulocerebellum Connections Afferents: receive input from vestibular nuclei and primary vestibular Efferents: projects to the vestibular nucleus → vestibulospinal tract and medial longitudinal fasciculus → motor neurons of anterior horn Function: involved in eye movements and maintain balance

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13 Connections and function of cerebellum
Spinocerebellum Connnection Afferents: receive somatic sensory information via spinocerebellar tracts

14 Efferents: Vermis projects to the fastigial nucleus → vestibular nuclei and reticular formation → vestibulospinal tract and reticulospinal tract → motor neurons of anterior horn Intermediate zone projects to the interposed nuclei Contralateral red nucleus → rubrospinal tract →motor neurons of anterior horn Contralateral VI →cerebral cortex→ coticospinal tract→motor neurons of anterior horn Function: play an important role in control of muscle tone and coordination of muscle movement on the same side of the body

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16 Connections and function of cerebellum
Cerebrocerebellum Connection Afferents: receives input from the cerebral cortex via a relay in pontine nuclei Efferents: projects to dentate nucleus → VI → primary motor cortex → corticospinal tract → motor neurons of anterior horn Function: participates in planning movements

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18 小脑的分叶和功能 前庭小脑－古小脑 － 绒球小结叶 维持身体姿势平衡和协调眼球运动 脊髓小脑－旧小脑 包括蚓垂、蚓锥体和前叶
脊髓小脑－旧小脑 包括蚓垂、蚓锥体和前叶 控制运动中的肢体远端肌的肌张力和协调 大脑小脑－新小脑:协调肢体的随意运动，使运动更精确

19 小脑损伤的临床表现 小脑是运动的重要调节中枢，有大量的传入和传出联系。大脑皮质发向肌肉的运动信息和执行运动时来自肌肉和关节等的信息，都可传入小脑。小脑经常对这两种传来的神经冲动进行整合，并通过传出纤维调整和纠正各有关肌肉的运动，使随意运动保持协调。此外，小脑在维持身体平衡上也起着重要作用。它接受来自前庭器官的信息，通过传出联系，改变躯体不同部分肌肉的张力，使肌体在重力作用下，作加速或旋转运动时保持姿势平衡。此外，据研究，小脑对内脏机能活动也有一定作用。小脑损伤引起的功能障碍是同侧性的。小脑受损伤后功能障碍主要表现为：肌张力低下，肌肉弛缓，如出现小腿呈钟摆样反射；随意运动发生障碍，表现为运动的速度、范围、力量和方向不准确，如步态失调，动作笨拙；平衡障碍，如躯体不易维持直立姿势，而向受损侧倾斜；植物性神经系统功能障碍，如尿失禁。

20 The Diencephalon

21 Position Position: Lies between midbrian and cerebrum, almost entirely surrounded by cerebral hemisphere

22 Subdivision Doral thalamus Metathalamus Epithalamus Subthalamus
Hypothalamus

23 Dorsal thalamus External features A large egg-shaped nucleus mass,
Anterior end called anterior thalamic tubercle, Posterior end called pulvinar Right and left portion of thalamus are joined by interthalamic adhesion Floor－hypothalamic sulcus

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25 Classification of nuclei of dorsal thalamus
Three nuclear group－divided by internal medullary lamina Anterior nuclear group Medial nuclear group Lateral nuclear group

26 internal medullary lamina
Med. nuclear group Dorsal tier Ant. nuclear group Pulvinar Ventral anterior Medial geniculate body (MGN) Ventral intermediate Ventral posterior nucleus (VP) Lateral geniculate body (LGN) Ventral posterolateral (VPL) Ventral posteromedial (VPM )

27 Subdivision Principal Nuclei Common abbreviation Ant. nuclear group Med. nuclear group Lat. nuclear group Dorsal tier Lateral dorsal LD Lateral posterior LP Pulvinar Ventral tier Ventral anterior VA Ventral intermediate VI Ventral posterior VP Ventral posterolateral VPL Ventral posteromedial VPM

28 Functional subdivision
Nonspecific relay nuclei－receive afferents from rhinencephalon and reticular formation of brain stem, project mainly to hypothalamus and corpus striatum Midline nucleus group Intralaminar nuclear group Thalamic reticular nucleus Association nuclei －receive input from many converging sours and in turn project widely to the association areas of cerebral cortex Anterior nuclear group Medial nuclear group Dorsal tier of lateral nuclear group

29 Special relay nuclei Vent. anterior nucleus (VA)
Vent. intermediate nucleus (VI) Receiving dentate nucleus, globus pallidus and substantia nigra to motor cortex Vent. posteromedial nucleus (VPM) －receives trigeminal lemniscus and teste fibers Vent. posterolateral nucleus (VPL) －receives medial lemniscus and spinal lemniscus Projects to first somatic sensory area via central thalamic radiation

30 Metathalamus Metathalamus Lateral geniculate body (LGN)
Medial geniculate body (MGN) Metathalamus

31 Metathalamus Medial geniculate body (MGN)
Relay station of audition Receive fibers from inferior colliculus Projects to auditory area via acoustic radiation Lateral geniculate body (LGN) Relay station of vision Receive fibers from optic tract Projects to visual area via optic radiation

32 Epithalamus Includes Thalamic medullary stria Habenular trigone
Habenular commissure Pineal body posterior commissure

33 Hypothalamus Position－lies ventral to thalamus Boundaries
Superiorly: hypothalamic sulcus Inferiorly: optic chiasma tuber cinereum Infundibulum mamillary body Anterior: lamina terminalis Posterior: continues with midbrain tegmentum

34 Subthalamus底丘脑 Transition zone between diencephalons and tegmentum of midbrain Contain subthalamic nucleus(底丘脑核), parts of red nucleus and substantia nigra

35 Subdivisions Preoptic region 视前区 Supraoptic region 视上区
Tuberal region 结节区 Mamillary region 乳头体区

36 Important nuclei Supraoptic region 视上区 Tuberal region 结节区
Supraoptic nucleus 视上核－produce antidiuretic hormone 抗利尿激素(ADH， vasopressin 加压素) Paraventricular nucleus 室旁核－produce oxytocin 催产素 Tuberal region 结节区 Infundibular nucleus 漏斗核 Ventromedial nucleus 腹内侧核 Dorsomedial nucleus 背内侧核 Mamillary region 乳头体区 Mamillary nucleus 乳头体核 Posterior hypothalamic nucleus 下丘脑后核

37 Paraventricular nucleus
Paraventriculohypophyeal tract Supraoptic nucleus Mamillary nucleus Supraopticohypophyseal tract arcuate nucleus tuberoinfundibular tract infundibulum anterior lobe of hypophsis posterior lobe of hypophysis

38 Hypothalamus --connection
Connects with limbic system Connects with brainstem and spinal cord Connects with dorsal thalamus Connects with hypophysis

39 Hypothalamus --connection
Supraoptic nucleus →supraoptic nucleus (ADH) →supraopticohypophyseal tract →posterior lobe of hypophysis Paraventricular nucleus → paraventicular nucleus (oxytocin) →paraventriculohypophyseal tract→posterior lobe of hypophysis

40 Paraventricular nucleus
Paraventriculohypophyseal tract Supraoptic nucleus Supraopticohypophyseal trac Inferior hypophyseal a. posterior lobe of hypophysis Hypophyseal v.

41 Parvicellular neurons in the arcuate nucleus and nearby region of the walls of the third ventricle secrete releasing and inhibiting hormones → tuberoinfundibular tract →portal vein of hypophsis → anterior lobe of hypophsis Tuberoinfundibular tract Median eminence Portal v. Superior hypophyseal a. anterior lobe Hypophyseal v.

42 Hypothalamus Function Regulates functions of neuroendocrine system
Autonomic nervous system

43 Third ventricle Communication
Position: a narrow ventricle cleft lies within diencephalons Boundaries Roof: choroids plexus Floor: optic chiasma, tuber cinereum, infundibulum and mamillary body Anterior: lamina terminalis Posterior: continuous with mesencephalic aqueduct Lateral wall: dorsal thalamus and hypothalamus Communication Third ventricle →mesencephalic aqueduct → fourth ventricle