俞靓 Elsevier生命科学产品客户顾问

俞靓 Elsevier生命科学产品客户顾问
Embase中的生命科学信息查询俞靓 Elsevier生命科学产品客户顾问

提纲 Embase简介 Embase中的检索 Embase检索小结 Embase中的内容 Embase中的索引与应用

什么是Embase Embase是领先的生物医学文献数据库，具有最全面的期刊和会议报道，生命科学索引体系和强大的搜索引擎，能帮助科研人员从错综复杂的全文中快速定位最关关键的内容。 Pharma A&G Medical Devices

>2,750 Journals not available
Embase中的内容 Embase >2,750 Journals not available on MEDLINE >8000 journals / 35 Million records! 药物，疾病，器械的深度索引，索引词表是Medline的2倍以上基于摘要，深度索引词的独特搜索引擎允许保存、共享和编辑复杂搜索策略 2009年以来的超过9300 个会议，超过 300万条会议记录更多的非英文文献的覆盖

Embase中拥有更多的国际内容覆盖

生物医药检索中的一种常见的漏检类型这是一篇关于联合使用钙离子拮抗剂，β受体阻滞剂，用于降压的一篇报道，
摘要中只出现了4个药物，阿替洛尔、硝苯地平、拉西地平及舍曲林一起应有可以相互抵消其副作用

全文中的内容我们通过阅读全文，发现还有第5种药物出现，Fluoxetinee。
氟西汀,是一种选择性血清再吸收抑制剂(SSRI)型的抗抑文献检索中，仅仅通过检索题录，摘要，远远不能满足循证方面的要求。

Medline中的记录 Medline中没有提炼，所以当用Fluoxetinee进行检索的时候，会漏掉

Embase中的记录

Embase的全文深度索引 Embase内容预览从全文中抽提最相关内容提炼内容可用于标记和检索依据Emtree将索引词标准化

深度挖掘后的索引标准化 Title Abstract Drug terms Disease terms Other terms

标准化后的逻辑关系搭建—三层索引体系的搭建
文献中的词条全部通过Emtree做过标准化处理

Embase登录界面 www.embase.com 基本检索模块快速检索 PICO PV Wizard 高级检索药物检索疾病检索
器械检索文献检索作者检索浏览模块 Emtree检索期刊检索

Embase中的词语连结利用布尔运算符可以将多个词语进行连接 and， or，not near/n, next/n

Emtree—Embase的核心索引体系
帮助创建最适当的检索式树结构包含15个层次。每个层次代表一个大类学科（解剖学、生物化学、药物、疾病、医疗技术与设备，病人组，等）。

提纲 Embase简介 Embase中的检索 Embase检索小结 Embase中的内容 Embase中的与索引与应用

Case Study 1 生物医药类文献的查询检索和CDK4/6靶点相关的文献 Tips：选择检索范围
涉及多个检索项的时候，需要考虑之间的关系直接输入CDK，系统可以给出Emtree中相关词汇，

获得结果 Tips：可以利用这里更多的工具，获得更加精准的文献。

Maping工具的使用 Tips：通过不同的匹配度进行结果的扩展或者精炼 Embase mapping options
Map to preferred term in Emtree 用Emtree中匹配的词去检索Index Term部分 Search also as free text in all fields 用输入的词检索所有字段 Explode using narrower Emtree terms 用Emtree中匹配的词以及这些词的下位词检索Index Term部分 Search as broadly as possible Emtree的词，下位词，同义词，Free Text检索所有字段 Limit to terms indexed in articles as “major focus”: 将检索词锁定在Major Focus部分

Major Focus结果 Tips： Embase将所有的检索历史列举在接口，可以随时查看，方便结果集之间的逻辑关系
可以通过Filter工具进一步对结果进行筛选

Filter工具的使用 Tips： Embase能帮助检索到很多Medline检索不到的文献
Study Tpye分析，帮助获得文献涉及的最直接的研究方向。

更多的Filter工具—Diseases
Tips： Disease分析，帮助从疾病领域出发，对文献进行筛选，获得这个靶点可能从事的疾病的研究在Subheading中可以获得更加细节性的内容，包括药物治疗，不良反应等，一些在研/上市的药物名称也可以通过这种方式获得。

更多的Filter工具—Drugs Tips：
进一步的Durg分析可以从药物的角度帮助获得文献中涉及到的药物不良反应，药物联用，药物比较等细节性的内容所有的检索，筛选历史全部位于History的部分，用于掌握结果的检索逻辑。

其中一条记录可以打开药物和疾病的词条查看文献中的关键内容

药物方面词条文献中报道的不良反应：腹泻、疲劳、高转氨酶血症、白细胞减少、粘膜炎症、中性粒细胞减少、皮疹文献中报道的联用信息：
阿那曲唑、联苯双酯、氟维司琼、GEDTA、Gelelelin、来曲唑、培妥珠单抗、曲妥珠单抗文献中报道的药物对比信息：环磷酰胺、多西他赛、表阿霉素、氟尿嘧啶、紫杉醇、安慰剂文献中报道的药物治疗信息：乳腺癌与转移性乳腺癌

Case Study 2 会议的查询获得2017 ASCO会议内容

检索的结果

药物警戒检索的构成这部分往往就是药物警戒需要看的文献与药物不良反应相关的词特殊的一些条件人的设定
[adverse drug reaction] 11.7M 与药物不良反应相关的词 'paracetamol-induced':ab,ti OR ('adverse drug reaction'/exp OR 'adverse drug reaction':lnk OR adverse:de,ab,ti OR ((side OR undesirable OR unwanted) NEXT/2 (effect* OR reaction* OR event* OR outcome*)):de,ab,ti OR 'side effect'/lnk OR 'side effect'/exp OR 'complication'/lnk OR 'complication'/exp OR complication*:de,ab,ti OR 'worsening':de,ab,ti OR 'case report*':de,ab,ti OR 'pharmacovigilance':de,ab,ti OR 'postmarketing surveillance'/exp OR 'drug interaction':lnk OR 'drug interaction'/exp OR 'toxicity'/exp OR 'drug toxicity':lnk OR toxic*:de,ab,ti OR intox*:de,ab,ti OR 'safety':de,ab,ti OR poison*:de,ab,ti OR pharmacotox*:de,ab,ti OR neurotox*:de,ab,ti OR cardiotox*:de,ab,ti OR nephrotox*:de,ab,ti OR hepatotox*:de,ab,ti OR immunotox*:de,ab,ti OR immunocytotox*:de,ab,ti OR cytotox*:de,ab,ti OR carcinogen*:de,ab,ti OR cancerogen*:de,ab,ti OR mutagen*:de,ab,ti OR terato*:de,ab,ti OR 'fatal outcome'/exp OR 'death'/exp OR death*:de,ab,ti OR 'suicide'/exp OR suicid*:de,ab,ti OR mortal*:de,ab,ti OR fatal*:de,ab,ti OR 'risk'/exp OR nocebo:de,ab,ti OR 'lethal concentration'/exp OR 'iatrogenic disease'/exp OR 'fertility'/exp OR 'substance-related disorders'/exp OR 'chemically induced':de,ab,ti OR 'morbidity':de,ab,ti OR 'congenital disorder':de,ab,ti OR infertility/exp OR injury/exp) 特殊的一些条件 'pregnancy'/exp OR pregnant*:de,ab,ti OR pregnanc*:de,ab,ti OR 'pregnancy complication'/exp OR 'pregnancy disorder'/exp OR 'abortion'/exp OR 'abortion':de,ab,ti OR 'lactation'/exp OR 'breast feeding':de,ab,ti OR 'breastfeeding':de,ab,ti OR 'breast milk':de,ab,ti OR 'reproduction'/de OR 'fetus'/de OR 'embryo'/de OR 'prenatal':de,ab,ti OR 'perinatal':de,ab,ti OR 'newborn':de,ab,ti OR ‘parameters concerning the fetus, newborn and pregnancy’/exp OR aged/exp OR elderly:de,ti,ab OR geriatric*:ti,ab OR ((environmental OR occupational) NEXT/1 exposure*):de,ab,ti OR 'compassionate use':de,ab,ti OR (named NEXT/1 (use OR patient*)):ab,ti OR 'inappropriate prescri*':de,ab,ti OR 'drug metabolism'/exp OR 'organ dysfunction':de,ab,ti OR 'organ failure':de,ab,ti OR 'hypersensitivit*':de,ab,ti OR allerg*:de,ab,ti OR counterfeit:de,ab,ti OR 'falsified drug':de,ab,ti OR ('unavailab*' NEAR/2 drug):de,ab,ti OR 'drug resistance'/exp OR 'drug resistance':de,ab,ti OR 'withdrawal syndrome'/de OR (drug* NEAR/3 (withdrawal OR toleran* OR interact* OR exposure* OR induc* OR resist* OR ineff* OR nonrespon* OR unrespon*)):de,ab,ti OR 'drug tolerance'/exp OR ((drug* OR treatment) NEXT/1 (failure* OR contraindication*)):de,ab,ti OR 'medication error'/exp OR (near NEXT/1 miss*):ab,ti OR ineff*:ti OR nonrespon*:ti OR unrespon*:ti OR ((lack OR no OR non OR 'not') NEXT/2 (eff* OR respon*)):ab,ti OR 'device failure':de,ab,ti OR manufacturing near/3 (error or fault or mistake or failure or contamination or impurity) OR ‘patient compliance’/exp OR overdos*:de,ab,ti OR 'drug abuse'/exp OR abus*:de,ab,ti OR misus*:de,ab,ti OR 'off label':de,ab,ti OR unlicensed:de,ab,ti 人的设定 ('human'/exp OR human OR m?n OR wom?n OR child OR boy OR girl) 这部分往往就是药物警戒需要看的文献药物名称或者药物的不同表述形式 'paracetamol':de OR '4 acetamidophenol':tn,ab,ti OR '4 acetaminophenol':tn,ab,ti OR '4 acetylaminophenol':tn,ab,ti OR '4 hydroxyacetanilide':tn,ab,ti OR '4` hydroxyacetanilide':tn,ab,ti OR 'abenol':tn,ab,ti OR 'acamol':tn,ab,ti OR 'acamoli forte suppositories for kids':tn,ab,ti OR 'acenol':tn,ab,ti OR 'acephen':tn,ab,ti OR 'acet suppositories':tn,ab,ti OR 'acetalgin':tn,ab,ti OR 'acetamino phenol':tn,ab,ti OR 'acetaminophen':tn,ab,ti OR 'acetaminophene':tn,ab,ti OR 'acetaminophenol':tn,ab,ti OR 'acetamol':tn,ab,ti OR 'acetomenophen':tn,ab,ti OR 'acetylaminophenol':tn,ab,ti OR 'adorem':tn,ab,ti OR 'afebrin':tn,ab,ti OR … 药物相关副标题 'paracetamol'/'drug toxicity','drug interaction','adverse drug reaction' [drug names] [human limit] 19.9M [drug subheadings] [special conditions] 6.8M 繁琐的组合可以由5个部分组成 ADR includes: adverse drug reaction, drug toxicity and drug interaction由药物直接导致的不良反应、急慢性中毒的病例报告、药物与化学药物、其他药物和食品的不良相互作用 Special situation includes: 药物治疗错误、缺乏有效性、对没有充分科学根据而不被认可的适应证的用药 (off-label) 、药物的滥用与错用 Human limit: 剔出动物反应试验取交集

Build the full search strategy with structured guidance
① OR [② AND (③ OR ④)] AND ⑤ ① 'paracetamol'/'drug toxicity','drug interaction','adverse drug reaction' OR 'paracetamol-induced':de,ab,ti OR ('paracetamol':de OR '4 acetamidophenol':tn,ab,ti OR '4 acetaminophenol':tn,ab,ti OR '4 acetylaminophenol':tn,ab,ti OR '4 hydroxyacetanilide':tn,ab,ti OR '4` hydroxyacetanilide':tn,ab,ti OR 'abenol':tn,ab,ti OR 'acamol':tn,ab,ti OR 'acamoli forte suppositories for kids':tn,ab,ti OR 'acenol':tn,ab,ti OR 'acephen':tn,ab,ti OR 'acet suppositories':tn,ab,ti OR 'acetalgin':tn,ab,ti OR 'acetamino phenol':tn,ab,ti OR 'acetaminophen':tn,ab,ti OR 'acetaminophene':tn,ab,ti OR 'acetaminophenol':tn,ab,ti OR 'acetamol':tn,ab,ti OR 'acetomenophen':tn,ab,ti OR 'acetylaminophenol':tn,ab,ti OR 'adorem':tn,ab,ti OR 'afebrin':tn,ab,ti OR 'algiafin':tn,ab,ti OR 'algotropyl':tn,ab,ti OR 'alphagesic':tn,ab,ti OR 'alvedon':tn,ab,ti OR 'amadil':tn,ab,ti OR 'anacin 3':tn,ab,ti OR 'anaflon':tn,ab,ti OR 'analgiser':tn,ab,ti OR 'apamide':tn,ab,ti OR 'apap':tn,ab,ti OR 'apirex':tn,ab,ti OR 'apotel':tn,ab,ti OR 'arthralgen':tn,ab,ti OR 'atamel':tn,ab,ti OR 'ben-u-ron':tn,ab,ti OR 'benuron':tn,ab,ti OR 'biogesic':tn,ab,ti OR 'biogesic suspension':tn,ab,ti OR 'bodrex':tn,ab,ti OR 'calapol':tn,ab,ti OR 'calodol':tn,ab,ti OR 'calonal':tn,ab,ti OR 'calpol':tn,ab,ti OR 'causalon':tn,ab,ti OR 'cemol':tn,ab,ti OR 'christamol':tn,ab,ti OR 'claradol':tn,ab,ti OR 'clocephen':tn,ab,ti OR 'cp 500':tn,ab,ti OR 'cp500':tn,ab,ti OR 'dafalgan':tn,ab,ti OR 'daga':tn,ab,ti OR 'datril':tn,ab,ti OR 'depon':tn,ab,ti OR 'depyretin':tn,ab,ti OR 'dirox':tn,ab,ti OR 'dismifen':tn,ab,ti OR 'disprol':tn,ab,ti OR 'dolal':tn,ab,ti OR 'dolex':tn,ab,ti OR 'dolex 500':tn,ab,ti OR 'doliprane':tn,ab,ti OR 'dolitabs':tn,ab,ti OR 'dolofen':tn,ab,ti OR 'dolomol':tn,ab,ti OR 'dolorol':tn,ab,ti OR 'dolotemp':tn,ab,ti OR 'dolprone':tn,ab,ti OR 'doltem':tn,ab,ti OR 'drilan':tn,ab,ti OR 'dristan af':tn,ab,ti OR 'duorol':tn,ab,ti OR 'dymadon':tn,ab,ti OR 'efferalgan':tn,ab,ti OR 'efferalgan 500':tn,ab,ti OR 'efferalganodis':tn,ab,ti OR 'efferelgan':tn,ab,ti OR 'enelfa':tn,ab,ti OR 'eneril':tn,ab,ti OR 'eraldor':tn,ab,ti OR 'expandol':tn,ab,ti OR 'febrilix':tn,ab,ti OR 'fendon':tn,ab,ti OR 'fervex':tn,ab,ti OR 'fibrinol':tn,ab,ti OR 'fortolin':tn,ab,ti OR 'gelocatil':tn,ab,ti OR 'geluprane 500':tn,ab,ti OR 'gunaceta':tn,ab,ti OR 'headache strength allerest':tn,ab,ti OR 'hedex':tn,ab,ti OR 'infants` feverall':tn,ab,ti OR 'injectapap':tn,ab,ti OR 'janupap':tn,ab,ti OR 'kamolas':tn,ab,ti OR 'kyofen':tn,ab,ti OR 'lemgrip':tn,ab,ti OR 'letamol':tn,ab,ti OR 'liquiprin':tn,ab,ti OR 'lotemp':tn,ab,ti OR 'lyteca':tn,ab,ti OR 'malidens':tn,ab,ti OR 'medamol':tn,ab,ti OR 'meforagesic':tn,ab,ti OR 'metagesic':tn,ab,ti OR 'metalid':tn,ab,ti OR 'mexalen':tn,ab,ti OR 'milidon 500':tn,ab,ti OR 'minopan':tn,ab,ti OR 'mypara':tn,ab,ti OR 'n acetyl 4 aminophenol':tn,ab,ti OR 'n acetyl para aminophenol':tn,ab,ti OR 'n-acetyl-p-aminophenol':tn,ab,ti OR 'nalgesik':tn,ab,ti OR 'napamol':tn,ab,ti OR 'napap':tn,ab,ti OR 'naprex':tn,ab,ti OR 'nektol 500':tn,ab,ti OR 'neocitran':tn,ab,ti OR 'neodalmin':tn,ab,ti OR 'neopap':tn,ab,ti OR 'nevral':tn,ab,ti OR 'nilapur':tn,ab,ti OR 'nobedon':tn,ab,ti OR 'nysacetol':tn,ab,ti OR 'ofirmev':tn,ab,ti OR 'pacemol':tn,ab,ti OR 'pacimol':tn,ab,ti OR 'pamal':tn,ab,ti OR 'pamol':tn,ab,ti OR 'panadol':tn,ab,ti OR 'panadol actifast':tn,ab,ti OR 'panadol soluble':tn,ab,ti OR 'panamax':tn,ab,ti OR 'panasorb':tn,ab,ti OR 'panodil':tn,ab,ti OR 'para acetamidophenol':tn,ab,ti OR 'para acetylaminophenol':tn,ab,ti OR 'para hydroxyacetanilide':tn,ab,ti OR 'para suppo':tn,ab,ti OR 'paracet':tn,ab,ti OR 'paracetaminophenol':tn,ab,ti OR 'paracetamol':tn,ab,ti OR 'paracetamol ester':tn,ab,ti OR 'paracetamole':tn,ab,ti OR 'parageniol':tn,ab,ti OR 'paragin':tn,ab,ti OR 'paralen':tn,ab,ti OR 'paralief':tn,ab,ti OR 'paramax':tn,ab,ti OR 'paramidol':tn,ab,ti OR 'parapaed':tn,ab,ti OR 'parapaed junior':tn,ab,ti OR 'parapaed six plus':tn,ab,ti OR 'paratabs':tn,ab,ti OR 'parvid':tn,ab,ti OR 'pasolind':tn,ab,ti OR 'pasolind n':tn,ab,ti OR 'paximol':tn,ab,ti OR 'pedipan':tn,ab,ti OR 'penral-night':tn,ab,ti OR 'perfalgan':tn,ab,ti OR 'phenaphen':tn,ab,ti OR 'pinex':tn,ab,ti OR 'polarfen':tn,ab,ti OR 'predimol':tn,ab,ti OR 'puernol':tn,ab,ti OR 'pyrigesic':tn,ab,ti OR 'raperon':tn,ab,ti OR 'rapidol':tn,ab,ti OR 'relaphen':tn,ab,ti OR 'reliv':tn,ab,ti OR 'remedol':tn,ab,ti OR 'revanin':tn,ab,ti OR 'rhinapen elixir':tn,ab,ti OR 'rhodapap':tn,ab,ti OR 'roxamol gelcaps':tn,ab,ti OR 'salzone':tn,ab,ti OR 'sedes a':tn,ab,ti OR 'serimol':tn,ab,ti OR 'setamol':tn,ab,ti OR 'sinaspril':tn,ab,ti OR 'sinedol':tn,ab,ti OR 'sinpro':tn,ab,ti OR 'tabalgin':tn,ab,ti OR 'tachipirin':tn,ab,ti OR 'tachipirina':tn,ab,ti OR 'taganopain':tn,ab,ti OR 'tapar':tn,ab,ti OR 'tempra':tn,ab,ti OR 'tempte':tn,ab,ti OR 'temzzard':tn,ab,ti OR 'termofren':tn,ab,ti OR 'tralgon':tn,ab,ti OR 'tralgon elixir':tn,ab,ti OR 'tramil':tn,ab,ti OR 'treuphadol':tn,ab,ti OR 'turpan':tn,ab,ti OR 'tylenol':tn,ab,ti OR 'tylenol (caplet)':tn,ab,ti OR 'tylenol (geltab)':tn,ab,ti OR 'tylenol extra fuerte':tn,ab,ti OR 'tylenol forte':tn,ab,ti OR 'tylenol nr 1':tn,ab,ti OR 'tylex':tn,ab,ti OR 'valadol':tn,ab,ti OR 'winadol':tn,ab,ti OR 'winasorb':tn,ab,ti OR 'xebramol':tn,ab,ti OR 'zolben':tn,ab,ti OR 'zydinol':tn,ab,ti AND ('adverse drug reaction'/exp OR 'adverse drug reaction':lnk OR adverse:de,ab,ti OR ((side OR undesirable OR unwanted) NEXT/2 (effect* OR reaction* OR event* OR outcome*)):de,ab,ti OR 'side effect'/lnk OR 'side effect'/exp OR 'complication'/lnk OR 'complication'/exp OR complication*:de,ab,ti OR 'worsening':de,ab,ti OR 'case report*':de,ab,ti OR 'pharmacovigilance':de,ab,ti OR 'postmarketing surveillance'/exp OR 'drug interaction':lnk OR 'drug interaction'/exp OR 'toxicity'/exp OR 'drug toxicity':lnk OR toxic*:de,ab,ti OR intox*:de,ab,ti OR 'safety':de,ab,ti OR poison*:de,ab,ti OR pharmacotox*:de,ab,ti OR neurotox*:de,ab,ti OR cardiotox*:de,ab,ti OR nephrotox*:de,ab,ti OR hepatotox*:de,ab,ti OR immunotox*:de,ab,ti OR immunocytotox*:de,ab,ti OR cytotox*:de,ab,ti OR carcinogen*:de,ab,ti OR cancerogen*:de,ab,ti OR mutagen*:de,ab,ti OR terato*:de,ab,ti OR 'fatal outcome'/exp OR 'death'/exp OR death*:de,ab,ti OR 'suicide'/exp OR suicid*:de,ab,ti OR mortal*:de,ab,ti OR fatal*:de,ab,ti OR 'risk'/exp OR nocebo:de,ab,ti OR 'lethal concentration'/exp OR 'iatrogenic disease'/exp OR 'fertility'/exp OR 'substance-related disorders'/exp OR 'chemically induced':de,ab,ti OR 'morbidity':de,ab,ti OR 'congenital disorder':de,ab,ti OR infertility/exp OR injury/exp OR 'pregnancy'/exp OR pregnant*:de,ab,ti OR pregnanc*:de,ab,ti OR 'pregnancy complication'/exp OR 'pregnancy disorder'/exp OR 'abortion'/exp OR 'abortion':de,ab,ti OR 'lactation'/exp OR 'breast feeding':de,ab,ti OR 'breastfeeding':de,ab,ti OR 'breast milk':de,ab,ti OR 'reproduction'/de OR 'fetus'/de OR 'embryo'/de OR 'prenatal':de,ab,ti OR 'perinatal':de,ab,ti OR 'newborn':de,ab,ti OR ‘parameters concerning the fetus, newborn and pregnancy’/exp OR aged/exp or elderly:de,ti,ab or geriatric*:ti,ab OR ((environmental OR occupational) NEXT/1 exposure*):de,ab,ti OR 'compassionate use':de,ab,ti OR (named NEXT/1 (use OR patient*)):ab,ti OR 'inappropriate prescri*':de,ab,ti OR 'drug metabolism'/exp OR 'organ dysfunction':de,ab,ti OR 'organ failure':de,ab,ti OR 'hypersensitivit*':de,ab,ti OR allerg*:de,ab,ti OR counterfeit:de,ab,ti OR 'falsified drug':de,ab,ti OR ('unavailab*' NEAR/2 drug):de,ab,ti OR 'drug resistance'/exp OR 'drug resistance':de,ab,ti OR 'withdrawal syndrome'/de OR (drug* NEAR/3 (withdrawal OR toleran* OR interact* OR exposure* OR induc* OR resist* OR ineff* OR nonrespon* OR unrespon*)):de,ab,ti OR 'drug tolerance'/exp OR ((drug* OR treatment) NEXT/1 (failure* OR contraindication*)):de,ab,ti OR 'medication error'/exp OR (near NEXT/1 miss*):ab,ti OR ineff*:ti OR nonrespon*:ti OR unrespon*:ti OR ((lack OR no OR non OR 'not') NEXT/2 (eff* OR respon*)):ab,ti OR 'device failure':de,ab,ti OR manufacturing near/3 (error or fault or mistake or failure or contamination or impurity) OR ‘patient compliance’/exp OR overdos*:de,ab,ti OR 'drug abuse'/exp OR abus*:de,ab,ti OR misus*:de,ab,ti OR 'off label':de,ab,ti OR unlicensed:de,ab,ti) AND ('human'/exp OR human OR m?n OR wom?n OR child OR boy OR girl)) ② ③ ④ What they need to do is (1) to just type in the drug name in the first part (2) then select synonyms from the provided list in this part (3) (4) (5) The following 3 parts are the pre-coded search queries. Customers can adopt these parts directly and take it from here and optimize the terms further. (6) These 5 parts are automatically connected by the correct Boolean operators ([drug]/[subheadings] OR ([drug names] AND ([adverse drug reaction] OR [special conditions])) AND [human limit]) ⑤ Designed to produce 100% recall against the gold set (in appendix).

Embase中的PV检索模块 Embase与EMA合作的PV检索模块

Case Study 3：Embase与EMA合作用于PV检索的模块

检索结果

Case Study 4：Embase中的PV检索
克唑替尼/赛可瑞：肺癌靶向药，辉瑞研制，于2011年获FDA批准用于ALK阳性转移性非小细胞肺癌患者的治疗，极大地改变了ALK阳性晚期NSCLC的临床治疗。2013年1月，克唑替尼在国内被批准上市。《药品不良反应报告和监测管理办法》 …新药监测期内的国产药品应当报告该药品的所有不良反应；其他国产药品，报告新的和严重的不良反应。进口药品自首次获准进口之日起5年内，报告该进口药品的所有不良反应；满5年的，报告新的和严重的不良反应。 …进口药品和国产药品在境外发生的严重药品不良反应（包括自发报告系统收集的、上市后临床研究发现的、文献报道的），药品生产企业应当填写《境外发生的药品不良反应/事件报告表》，自获知之日起30日内报送国家药品不良反应监测中心… 药品不良反应报告和监测管理办法：进口药品和国产药品在境外发生的严重药品不良反应（包括自发报告系统收集的、上市后临床研究发现的、文献报道的），药品生产企业应当填写《境外发生的药品不良反应/事件报告表》，自获知之日起30日内报送国家药品不良反应监测中心同类型批准上市药物：易瑞沙/吉非替尼：2005年2月25日在中国上市，用于治疗既往接受过化学治疗的局部晚期或转移性非小细胞肺癌伊瑞可/吉非替尼：齐鲁制药研制， 2017年2月18日上市，适用于表皮生长因子受体(EGFR)基因具有敏感突变的局部晚期或转移性非小细胞肺癌(NSCLC)患者的一线治疗。特罗凯/厄洛替尼：罗氏，2007年3月17日在中国上市，适用于既往接受过至少一个化疗方案失败后的局部晚期或转移的非小细胞肺癌（NSCLC）。凯美纳/埃克替尼：贝达药业， 2011年8月上市，适应症为本品单药适用于治疗既往接受过至少一个化疗方案失败后的局部晚期或转移性非小细胞肺癌(NSCLC)，既往化疗主要是指以铂类为基础的联合化疗。吉泰瑞/阿法替尼：德国勃林格殷格翰， 2017年2月27日在中国上市，用于经铂为基础的化疗治疗后进展的晚期肺鳞癌患者的二线治疗。奥希替尼/AZD9291/泰瑞莎：阿斯利康， 2017年3月24日在中国上市，适用于既往经表皮生长因子受体(EGFR)酪氨酸激酶抑制剂(TKI)治疗时或治疗后出现疾病进展，并且经检测确认存在EGFR T790M突变阳性的局部晚期或转移性非小细胞性肺癌（NSCLC）成人患者的治疗。

Embase中的检索步骤输入商品名，自动转换成Emtree中的词

药物相关名称的添加

预设的和PV有关的一些词条可以根据药物的类型，添加一些字条：前缀词+*:de,ab,ti 单引号标记词组+/exp OR的关系

Special Situations的添加
预设的一些条件：妊娠或母乳喂养期间、儿科，老年人群中使用医药产品、缺乏治疗效果、过量、滥用、错用、药物错误等

限定用于人体 2013年1月，克唑替尼在国内被批准上市。

最后的结果

邮件的提醒

Embase检索小结 Embase中完全包含Medline的内容， Embase中还包含更多的会议记录，以及更多的非英文文献
Embase中拥有强大的Emtree索引词库，帮助用户能更加精准的找到文献 Embase的Drug，Disease，PICO，PV等检索模块，能帮助用户在最短时间内，创建最精准的检索式 Embase的强大过滤工具，能帮助用户通过不同的手段进行文献方面的筛选和过滤

Sam Yu S.yu.2@Elsevier.com
谢谢 Sam Yu

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