Metabolic biomarker signature to differentiate pancreatic ductal adenocarcinoma from chronic pancreatitis Gut, 2017, Jan (IF=14.921) 汇报人：王宁 IMI CONFIDENTIAL.

Presentation on theme: "Metabolic biomarker signature to differentiate pancreatic ductal adenocarcinoma from chronic pancreatitis Gut, 2017, Jan (IF=14.921) 汇报人：王宁 IMI CONFIDENTIAL."— Presentation transcript:

1 Metabolic biomarker signature to differentiate pancreatic ductal adenocarcinoma from chronic pancreatitis Gut, 2017, Jan (IF=14.921) 汇报人：王宁 IMI CONFIDENTIAL

2 Background 代谢组学的概念来源于代谢组，代谢组是指某一生物或细胞在一特定生理时期内所有的低分子量代谢产物，代谢组学则是对某一生物或细胞在一特定生理时期内所有低分子量代谢产物同时进行定性和定量分析的一门新学科。它是以组群指标分析为基础，以高通量检测和数据处理为手段，以信息建模与系统整合为目标的系统生物学的一个分支。 代谢组学是继基因组学和蛋白质组学之后新近发展起来的一门学科，是系统生物学的重要组成部分。之后得到迅速发展并渗透到多项领域，比如疾病诊断、医药研制开发、营养食品科学、毒理学、环境学，植物学等与人类健康护理密切相关的领域。 IMI CONFIDENTIAL

3 Materials and Methods Pancreatic cancer Chronic pancreatitis
Sample preparation: 914 subjects Liver cirrhosis Healthy blood donors Metabolite profiling: MxP broad profiling, MxP steroids, MxP lipids GC-MS; LC-MS/MS; SPE-LC-MS/MS. Statistics IMI CONFIDENTIAL

4 Results Training set Test set IMI CONFIDENTIAL

5 Results IMI CONFIDENTIAL

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15 Thanks IMI CONFIDENTIAL