Targeting TYRO3 inhibits epithelial–mesenchymal transition and increases drug sensitivity in colon cancer C-W Chien, P-C Hou, H-C Wu, Y-L Chang, S-C Lin,

Targeting TYRO3 inhibits epithelial–mesenchymal transition and increases drug sensitivity in colon cancer C-W Chien, P-C Hou, H-C Wu, Y-L Chang, S-C Lin, S-C Lin, B-W Lin, J-C Lee, Y-J Chang, HS Sun, and S-J Tsai Oncogene , 2 May 2016; doi: /onc Q＆A

TAM family structure

Interaction of TAM family ＆ their ligands

TAM family pathway 除了ligand binding 刺激，也會跟同為RTK的Receptor進行交互作用，進而induce cancer prograssion

截至目前為止TYRO3在cancer的研究中，作用機轉扔待研究
Expression and function of TAM family kinases and ligands in specific tumor types TAM kinase 截至目前為止TYRO3在cancer的研究中，作用機轉扔待研究 Lligands ：colorectal cancer(CRC) Nature Reviews Cancer 14, 769–785 (2014) doi: /nrc3847

Somatic TAM family kinase mutations in cancer
Nature Reviews Cancer 14, 769–785 (2014) doi: /nrc3847

Summary 根據Key data所整理出的表格，可以推論，在CRC中TYRO3 不僅受Ligand ( Galectin3 )的刺激，也可能是因為cytosolic domain mutaion 造成不斷的Autophosphorylation而因此致癌，但相關的機轉扔待後續研究確認。

Targeting TYRO3 inhibits epithelial–mesenchymal transition and increases drug sensitivity in colon cancer C-W Chien, P-C Hou, H-C Wu, Y-L Chang, S-C Lin,

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Targeting TYRO3 inhibits epithelial–mesenchymal transition and increases drug sensitivity in colon cancer C-W Chien, P-C Hou, H-C Wu, Y-L Chang, S-C Lin,

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Presentation on theme: "Targeting TYRO3 inhibits epithelial–mesenchymal transition and increases drug sensitivity in colon cancer C-W Chien, P-C Hou, H-C Wu, Y-L Chang, S-C Lin,"— Presentation transcript:

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