胚胎學 陳建榮 http://web.nchu.edu.tw/pweb/users/chenjr/
教科書及參考資料： 1. The Developing Human (9TH, 2013, by Keith L. Moore & T. V. N. Persaud) 2. Langman’s medical embryology (12th, 2012, by T.W. Sadler) 3. Veterinary embryology (2006, by McGeady et al.) 4. Domestic animal embryology (2010, by Hyttel et al.) 5. http://embryology.med.unsw.edu.au/ 6. 講義 評量方式： 期中考 (45%) 期末考 (45%) 平時成積 (10%)
Topics 配子的形成與受精 受精卵的著床與胚胎成形 各系統的正常或異常發育與臨床疾病的關係 畸胎學
Embryology Animal development is a continuous process that begins when a zygote is formed Development does not stop at birth
Developmental Periods Gametogenesis Spermatogenesis Oogenesis Prenatal period (Fertilization) Embryo: Zygote Cleavage Implantation Gastrulation… Organogenesis Fetus Postnatal period Neonate (<1 month) Infancy (< 1 yr) Childhood Puberty (13 yr – 16 yr) Adulthood
胎齡: LNMP (last normal menstrual period) embryo fetus Trimester
Carnegie stages are a system used by embryologists to describe the apparent maturity of embryos 1st trimester
1st week
Formation of Bilaminar Embryonic Disc Stage 5: 7th –12th day full implantation 2nd week
Stages 6-9: Day 13-21 Somites 3rd week
Stages 10-17 4th to 6th week
Embryo (end of the 8th week) - all major structures are present 7 8 Embryo (end of the 8th week) - all major structures are present Fetus (after 8th week)
Data For Carnegie Stages Comparison Graph (Species/Days) 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 Human Days 24 28 30 33 36 40 42 44 48 52 54 55 58 Baboon 25 27 29 31 35 37 39 41 43 45 47 Rhesus Monkey 32 34 38 46 Marmoset 57 60 64 67 74 Mouse 9.5 10.5 11.5 12.5 13.5 14.5 15.5 Rat 16.5 17.5 Chinese Hamster Guinea Pig 26 Rabbit 8 8.5 Sheep 18.5 19.5 20.5 24.5 25.5 27.5 29.5 Pig 21.5 30.5 32.5 Chicken 1 1.5 2 2.25 2.5 3 3.25 3.75 4.75 5.5 6.25 7.25 7.75
Genetics and Molecular biology are applied in human development Ian Wilmut [1997] Somatic cell nuclear transfer – Dolly lamb Embryonic stem cell
Somatic cell nuclear transfer 桃莉羊與Ian Wilmut教授
複製動物的肉和乳品安全嗎？ 基因改良食品的安全性？
複製人類是否無可避免？聯合國管理下的未來選擇
Stem cell Embryonic stem cell Morula Blastocyt 組織修補 \ 器官替換 組織修補 \ 器官替換 人造器官(心臟、肺、支氣管…)
「救命寶寶」（rescue baby） 胚胎著床前基因診斷
全球首例 英允許「一父二母」基改寶寶 Dysfunctional mitochondria: Diabetes mellitus and deafness (DAD) Visual loss Seizures Dementia …
Anatomical position