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Pulmonary arterial hypertension; potential pathogenetic and pathobiologic mechanisms. (5-HTT, serotonin transporter gene; ALK-1, activin receptor-like kinase 1 gene; BMPR-2, bone morphogenetic receptor 2 gene; HIV, human immunodeficiency virus.) (Reproduced with permission from Galie N, Torbicki A, Barst R. Guidelines on diagnosis and treatment of pulmonary arterial hypertension. Eur Heart J 2004;25:2243-2278.) Source: Pulmonary Arterial Hypertension, Pharmacotherapy: A Pathophysiologic Approach, 10e Citation: DiPiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey L. Pharmacotherapy: A Pathophysiologic Approach, 10e; 2017 Available at: http://accesspharmacy.mhmedical.com/content.aspx?bookid=1861&sectionid=146058555 Accessed: September 06, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved

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Systemic Lupus Erythematosus 原先是在形容此類患者會有狼咬一般的紅斑

基因：先天的免疫、後天免疫、自體凋亡細胞的清除率、其他機制、環境影響 不正常的免疫反應： 自體抗體免疫複合體 Pathogenesis of SLE. Listed genes increase susceptibility to SLE or lupus nephritis. Gene–environment interactions result in abnormal immune responses that generate pathogenic autoantibodies and immune complexes that deposit in tissue, activate complement, cause inflammation, and lead to irreversible organ damage. Ag, antigen; C1q, complement system; C3, complement component; DC, dendritic cell; EBV, Epstein–Barr virus; HLA, human leukocyte antigen; FcR, immunoglobulin Fc-binding receptor; IL, interleukin; MCP, monocyte chemotactic protein; PTPN, phosphotyrosine phosphatase; UV, ultraviolet light. (From Hahn BH. Systemic lupus erythematosus. In: Longo DL, Fauci AS, Kasper DL, et al., eds. Harrison’s Principles of Internal Medicine. 18th ed. [electronic version]. 2012, Access Medicine. Chapter 319.) 紅斑性狼瘡的病因 基因：先天的免疫、後天免疫、自體凋亡細胞的清除率、其他機制、環境影響 不正常的免疫反應： 自體抗體免疫複合體 發炎反應：造成紅疹、腎炎、關節炎、白血球減少症、 器官損傷：腎臟衰竭、動脈粥狀硬化、肺纖維化、中風等 這些基因將增加紅斑性狼瘡或狼瘡腎炎的感受性 而基因和環境的交互作用下將導致不正常的免疫反應，生成病理性的自體免疫抗體及免疫複合體將囤積在組織中，活化補體，而造成發炎反應，甚至是不可逆的器官受損。 Source: Chapter 69. Systemic Lupus Erythematosus, Pharmacotherapy: A Pathophysiologic Approach, 9e Citation: DiPiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey L. Pharmacotherapy: A Pathophysiologic Approach, 9e; 2014 Available at: http://accesspharmacy.mhmedical.com/content.aspx?sectionid=48811477&bookid=689&Resultclick=2 Accessed: May 18, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved

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