18-3 課堂整理 第十五組 0993B010 張維哲 0993B042 游博雄
心智圖 citric acid cycle Aerobic NADH and Pyruvate Alcohol Fermentation Anaerobic Lactic Acid Fermentation Glucose Glycolysis Mannose Fructose galactose-1-phosphate uridylyltransferase Galactose The Leloir pathway Glycerol
The fate of NADH and Pyruvate POINT 1 The fate of NADH and Pyruvate 當細胞處於Aerobic時,NADH和Pyruvate自然地進入Krebs Cycle,但當細胞在anaerobic時,此時過多NADH和Pyruvate該何去何從呢?
Anaerobic Respiration (1)Alcohol Fermentation(發酵) 藉由 Alcohol dehydrogenase 將NADH 氧化,重新生成NAD+ (2)Lactic Acid Fermentation 藉由 lactate dehydrogenase
Anaerobic Respiration Alcohol Fermentation
Anaerobic Respiration Lactic Acid Fermentation
POINT 2 Are Substrates Other Than Glucose Used in Glycolysis? 難道只有Glucose才能夠進行Glycolysis嗎?那其他種類的醣就不行嗎?
1 )Mannose, 2)galactose, 3)fructose, 同樣也能夠進入 Glycolysis喔!
The Leloir pathway 其中最有趣的為Galactose(半乳糖) metabolism the Leloir pathway The galactose-1-phosphate uridylyltransferase 的反應包含了 “ping-pong” kinetic mechanism.
The Leloir pathway
“ping-pong” kinetic mechanism
Glycerol 也能夠進入 Glycolysis
習題解析 Why human use Lactic acid fermentation mainly but not Alcohol fermentation? A:因為藉由Alcohol fermentation作用會產生CO2,而CO2在溶入血液後形成H2CO3(aq)會影響血液中pH值濃度,並進一步影響個體的生理反應;而Lactic acid fermentation所產生之Lactic acid可被人體細胞代謝。