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甲地孕酮 谢一珂
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孕激素的生理及药理作用 促进子宫内膜增生 抑制子宫收缩 促进乳腺腺泡发育 抑制排卵 利尿 升高体温
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临床应用 先兆性及习惯性流产 功能性子宫出血 痛经和子宫内膜异位症 子宫内膜腺癌 前列腺肥大和前列腺癌 避孕
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临床运用之避孕 避孕效果:99.9%可避孕 必须坚持服用 需增加顺应性 与其他避孕方法比较：无显著性差异、 可减弱痛经、月经不调、治疗痤疮
不良反应：类假孕症状
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临床应用之女性特发性性早熟 性早熟：女性在8岁、男性在10岁前开始第二 性征发育。 包括:中枢性和外周性性早熟
性早熟：女性在8岁、男性在10岁前开始第二 性征发育。 包括:中枢性和外周性性早熟 GnRHa(促性腺激素释放激素）及其类似物（目前最常用） 甲地孕酮：对FAH无效且有继发性肾上腺功能减退 知柏地黄丸&甲地孕酮：效果好、经济
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甲地孕酮之其他 治疗乳腺癌和前列腺癌的一个明显副作用：增强食欲，体重增加。 治疗晚期癌症厌食-恶病质，但是……
对CACS引起的肌肉萎缩有一定作用 肾上腺功能减弱的副作用
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2017/9/12 参考文献 [1].Bodenner, D., et al., A retrospective study of the association betweenmegestrol acetate administration and mortality among nursing home residents with clinically significant weight loss. Am J Geriatr Pharmacother, (2): p [2].Bulchandani, D., et al., Megestrol acetate-associated adrenal insufficiency. Am J Geriatr Pharmacother, (3): p [3].Delitala, A.P., et al., Primary symptomatic adrenal insufficiency induced by megestrol acetate. Neth J Med, (1): p [5].Argiles, J.M., A. Anguera and B. Stemmler, A new look at an old drug for the treatment of cancer cachexia: Megestrol acetate. Clin Nutr, 2013. [6].马小旭, 中西医结合治疗小儿性早熟. 中国实验方剂学杂志, 2011(3). [7]史惠蓉，复方口服避孕药的避孕效果和依从性.国际生殖健康/计划生育杂志,2007（7）
![2017/9/12 参考文献. [1].Bodenner, D., et al., A retrospective study of the association betweenmegestrol.](http://slidesplayer.com/slide/11746325/65/images/7/2017%2F9%2F12+%E5%8F%82%E8%80%83%E6%96%87%E7%8C%AE.+%5B1%5D.Bodenner%2C+D.%2C+et+al.%2C+A+retrospective+study+of+the+association+betweenmegestrol..jpg "acetate administration and mortality among nursing home residents with clinically. significant weight loss. Am J Geriatr Pharmacother, (2): p [2].Bulchandani, D., et al., Megestrol acetate-associated adrenal insufficiency. Am J Geriatr Pharmacother, (3): p [3].Delitala, A.P., et al., Primary symptomatic adrenal insufficiency induced by. megestrol acetate. Neth J Med, (1): p [5].Argiles, J.M., A. Anguera and B. Stemmler, A new look at an old drug for the treatment of cancer cachexia: Megestrol acetate. Clin Nutr, [6].马小旭, 中西医结合治疗小儿性早熟. 中国实验方剂学杂志, 2011(3). [7]史惠蓉，复方口服避孕药的避孕效果和依从性.国际生殖健康/计划生育杂志,2007（7）")
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