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O-linked High mannose Glycoprotein N-linked Complex Hybrid Versican Serglycin Soluble Secorin Proteoglycan Cartilage Transmembrane Syndecan Selectin Lectin Galectin C-reactive protein
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重點整理 Glycoprotein O-linked：attach to hydroxyl groups * Usually N-acetylgalactosamine * 常有分支 * Functions：1. 增加彈性 增加水溶性
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N-linked：attach to the amide nitrogens * Have Core structure：
By two N-acetylglucosamine and a branched mannose triad. * Functions：1. 改變蛋白質的物理和化學性質 2. 穩定蛋白質構型 3. 幫助蛋白質折疊 Sialic acid：被修飾在N-linked 的最末端，會隨 著時間脫落，而被辨識
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Proteoglycans 大多為glycosaminoglycans (GAG) 在動物細胞膜、或細菌外殼
包含 soluble proteins：Versican, Serglycin, Secorin, Cartilage transmembrane proteins：Syndecan
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Functions： 1. 與其他蛋白質結合：成為ECM中的Blue、與
生長因子作用 2. 調控細胞生長的過程：抑制細胞增殖、刺 激生長因子 3. 關節的緩衝：ex. Cartilage
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Sugar Code and Lectins Sugar code：由 sugar 構成的訊號碼 Lectin：辨認sugar，或和sugar結合的蛋白質 ex. Selectin, Galectin, C-reactive protein (CRP)
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習題 Q：What are the differences between proteoglycans and glycoproteins A：glycoprotein= protein (major)＋glycan (minor) ex: Antifreeze Glycoproteins proteoglycan= core protein (minor)＋GAGs (major) ex: heparin
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