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Distinction of left ventricular non-compaction from dilated cardiomyopathy by cardiac magnetic resonance tissue tracking Xi Liu1,2, Zhi-gang Yang1,2*, Ying-kun Guo1,3, 1. Department of Radiology, Sichuan University, Chengdu, China 2. Department of Radiology, West China Hospital, Sichuan University, Chengdu, China 3. Department of Radiology, West China Second University Hospital, Sichuan University, Chengdu, China Abstract Purpose: The aim of this study was to analyze the value of cardiovascular magnetic resonance (CMR) tissue tracking to differentiate left ventricular non-compaction cardiomyopathy (LVNC) from dilated cardiomyopathy (DCM). Materials and Methods: We recruited 12 patients with LVNC and 12 DCM patients for CMR examination and measured left ventricular (LV) function and tissue tracking parameters, including global and regional (basal, middle and apical) radial, circumferential and longitudinal peak strain(PS), peak systolic strain rate (PSSR) and peak diastolic strain rate (PDSR). LV tissue tracking parameters were compared between LVNC patients and DCM patients. Results: Among the global tissue tracking parameters, radial PS (9.63 ± 4.57 % vs. 18.65 ± 13.22 %, p = 0.036), radial PDSR (-0.62 ± 0.40 1/s vs. -1.75 ± 1.36 1/s, p = 0.011), and circumferential PDSR (0.36 ± 0.19 1/s vs. 0.76 ± 0.49 1/s, p = 0.015) were significantly lower in DCM patients than in LVNC patients. Besides, both the radial PS, radial PDSR radial and circumferential PDSR of the basal, middle and apical regional were obviously lower in the DCM patients compared with the LVNC patients (all p< 0.05). Furthermore, within the LVNC patients, the Pearson’s correlation indicated an excellent correlation between the LVEDV and radial PS (r = −0.852, p< 0.001). Conclusions: CMR tissue tracking could be useful in differentiating between LVNC patients and patients with DCM, which could potentially be included as a supplementary diagnostic procedure in the evaluation of LVNC. Figure. 1. Features of DCM and LVNC patients shown by two- chamber views of cardiac magnetic resonance. Arrows point to the non-compaction myocardium in LVNC patient. Figure.2. CMR tissue tracking using cmr42 (Circle Cardiovascular Imaging Inc., Calgary, Canada) at short-axis (A), two-chamber (B), three-chamber (C) and four-chamber long-axis (D) cine images in LVNC patient.