抑郁症研究的动物模型 基础01级 陈瑶瑶

I am depressed. Me too.

Why we need animal models? The sorts of animal models. The future development of animal models.

The uses of animal models Antidepressants screening. Mechanism studying

神经生化功能改变模型 应激模型 条件性饲养模型 基因工程动物模型

获得性无助模型 (learned helpless) 慢性温和应激模型 (chronic mild stress) 行为绝望模型 (behavioral despair)

Gene-engineering mice Conventional transgenic mice Conditional gene-targeting methods Antisense targeting

5-HT1A受体敲除 抗抑郁表型 糖皮质激素受体基因损伤 抗抑郁表型，焦虑相关的行为减少(有待进一步确定) 5-HT1B受体敲除 拮抗抗抑郁表型，对SSRI类抗抑郁药敏感性增加 谷氨酸脱羧酶基因敲除 DA-β-羟化酶基因敲除 拮抗抗抑郁表型 神经细胞黏附分子基因敲除 α2A-肾上腺素能受体基因敲除 抑郁表型，并拮抗抗抑郁表型 TNFα基因敲除 α2C-肾上腺素能受体基因敲除 血管紧张素基因敲除 α2C-肾上腺素能受体基因过表达 抑郁表型 腺苷受体基因敲除 NE转运子基因敲除 速激肽NK1受体基因敲除 单胺氧化酶A基因敲除 IL-6基因敲除 单胺氧化酶B基因敲除 多巴胺D5受体基因敲除 μ阿片受体基因敲除 DARPP基因敲除 对盐酸氟西汀敏感性降低 δ阿片受体基因敲除 CREB突变 Gα-G-蛋白敲除 BDNF条件性基因敲除 抗抑郁表型，对电击敏感性降低 TrkB基因敲除 抗抑郁表型，对抗抑郁药敏感性降低

展望 实验动物模型是研究抑郁症必不可少的工具。随着基因工程技术的出现，实验模型的可操作性和多样性都大大改善了。虽然转基因技术仍存在很多问题，但其仍有着光明的前景。

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感谢： 肖远、陈怡、刘婷婷、王颖、李逸、阎焰、平星杰（排名不分先后） 感谢她们在本次讨论中的积极参与； 感谢王昕老师老师给我们这次机会； 感谢在座各位老师和同学给予的耐心。