生物信息学 第三章 基因组学与序列分析 张高川 生物信息学教研室 (Department of Bioinformatics)

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1 生物信息学 第三章 基因组学与序列分析 张高川 生物信息学教研室 (Department of Bioinformatics)
基础医学与生物科学学院 (School of Biology and Basic Medical Science) 苏州大学医学部 (Medical College of Soochow University) Tel: QQ:

2 What is genome or genomics?

3 What is genome or genomics?
Genome >> a haploid genome The term was adapted in 1920 by Hans Winkler (23 April 1877 – 22 November 1945) , professor of botany at the University of Hamburg, Germany. Nuclear /Chromosomal genome

4 What is genome or genomics?
Genome >> a haploid genome The term was adapted in 1920 by Hans Winkler (23 April 1877 – 22 November 1945) , professor of botany at the University of Hamburg, Germany. Nuclear /Chromosomal genome

5 What is genome or genomics?
Genome >> a haploid genome The term was adapted in 1920 by Hans Winkler (23 April 1877 – 22 November 1945) , professor of botany at the University of Hamburg, Germany. Nuclear /Chromosomal genome Mitochondrial genome

6 What is genome or genomics?
Genome >> a haploid genome The term was adapted in 1920 by Hans Winkler (23 April 1877 – 22 November 1945) , professor of botany at the University of Hamburg, Germany. Nuclear /Chromosomal genome Mitochondrial genome

7 What is genome or genomics?
Genome >> a haploid genome The term was adapted in 1920 by Hans Winkler (23 April 1877 – 22 November 1945) , professor of botany at the University of Hamburg, Germany. Nuclear /Chromosomal genome Mitochondrial genome Chloroplast genome

8 What is genome or genomics?
Genome >> a haploid genome The term was adapted in 1920 by Hans Winkler (23 April 1877 – 22 November 1945) , professor of botany at the University of Hamburg, Germany. Nuclear /Chromosomal genome Mitochondrial genome Chloroplast genome

9 What is genome or genomics?
Genome >> a haploid genome The term was adapted in 1920 by Hans Winkler (23 April 1877 – 22 November 1945) , professor of botany at the University of Hamburg, Germany. Nuclear /Chromosomal genome Mitochondrial genome Chloroplast genome

10 What is genome or genomics?
Genome >> a haploid genome The term was adapted in 1920 by Hans Winkler (23 April 1877 – 22 November 1945) , professor of botany at the University of Hamburg, Germany. Nuclear /Chromosomal genome Mitochondrial genome Chloroplast genome Virus genome

11 What is genome or genomics?
Genome >> a haploid genome The term was adapted in 1920 by Hans Winkler (23 April 1877 – 22 November 1945) , professor of botany at the University of Hamburg, Germany. Nuclear /Chromosomal genome Mitochondrial genome Chloroplast genome Virus genome

12 What is genome or genomics?
Genome >> a haploid genome The term was adapted in 1920 by Hans Winkler (23 April 1877 – 22 November 1945) , professor of botany at the University of Hamburg, Germany. Nuclear /Chromosomal genome Mitochondrial genome Chloroplast genome Virus genome The term genomics was coined in 1987 by Victor A. McKusick and Frank H. Ruddle as the title for a new journal of that name.  Genomics Genomics is a discipline in genetics that applies recombinant DNA, DNA sequencing methods, and bioinformatics to sequence, assemble, and analyze the function and structure of genomes.

13 (Human Genome Project, HGP) National Institutes of Health (NIH)
现代生命科学研究的一个大事件 人类基因组计划 (Human Genome Project, HGP) (30亿个碱基对) National Institutes of Health (NIH) 美国能源部人类基因组计划徽标 ； 30亿美元 英国、日本、法国、德国、中国、印度 1998 美国科学家克莱格·凡特 塞雷拉基因组公司 (Celera Genomics) , 克林顿 国际人类基因组组织（HUGO） 1998 1999年9月，中国正式加入HGP； 人类第3号染色体的短臂区域3000万个碱基对（1％）。 1999

14 (Human Genome Project, HGP)
人类基因组计划 (Human Genome Project, HGP) 30亿个碱基对 ? 数学方法 计算机技术 基因组注释 新基因发现 接下来，该怎么办？ 基因组比较

15 NCBI >> Genbank 选择Genome数据库, 空搜索直接进入

16 NCBI >> Genbank >> Genome
按物种类别浏览基因组数据库

17 NCBI >> Genbank >> Genome >> Browse by Organism

18 NCBI >> Genbank >> Genome
通过FTP方式下载基因组数据

19 NCBI >> Genbank >> Genome >> Download by FTP

20 NCBI >> Genbank >> Genome >> Download by FTP

21 NCBI >> Genbank >> Genome >> Download by FTP >> H_sapiens (人类)

22 NCBI >> Genbank >> Genome >> Download by FTP >> H_sapiens (人类) >> CHR_01

23 NCBI >> Genbank >> Genome >> Download by FTP (FileZilla)

24 NCBI >> Genbank >> Genome >> Download by FTP (FileZilla)

25 NCBI >> Genbank >> Genome >> Download by FTP (FileZilla)

26 NCBI >> Genbank >> Genome >> Download by FTP (FileZilla) >> CHR_Un

27 NCBI >> Genbank >> Genome >> Download by FTP (FileZilla) >> GFF

28 NCBI >> Genbank >> Genome
人类基因组资源

29 NCBI >> Genbank >> Genome >> 人类基因组资源

30 NCBI >> Genbank >> Gene >> TP53搜索结果

31 NCBI >> Genbank >> Gene >> TP53

32 NCBI >> Genbank >> Gene >> TP53

33 NCBI >> Genbank >> Gene >> TP53 >> Map Viewer

34 TNCBI >> Genbank >> Gene >> TP53 >> Map Viewer >> 负链编码基因
S

35 TNCBI >> Genbank >> Gene >> TP53 >> Map Viewer >> 负链编码基因
S

36 TNCBI >> Genbank >> Gene >> TP53 >> Map Viewer >> 下载序列

37 Genome和Genomics相关文献资料查阅 Genbank数据库之Genome子库使用练习
拓展阅读和实践练习 Genome和Genomics相关文献资料查阅 Genbank数据库之Genome子库使用练习

38 TNCBI >> Genbank >> Gene >> TP53 >> Map Viewer >> 下载序列 >> FASTA格式

39 Genome和Genomics相关文献资料查阅 Genbank数据库之Genome子库使用练习
拓展阅读和实践练习 Genome和Genomics相关文献资料查阅 Genbank数据库之Genome子库使用练习

40 Thanks for your attention！