性别决定与表观遗传 陈德桂 中科院上海生科院生化与细胞所 cdchen@sibs.ac.cn 021-54921148.

Presentation on theme: "性别决定与表观遗传 陈德桂 中科院上海生科院生化与细胞所 cdchen@sibs.ac.cn 021-54921148."— Presentation transcript:

1 性别决定与表观遗传 陈德桂 中科院上海生科院生化与细胞所

2 性别决定 Sex is determined by sex chromosome sex chromosome

3 SRY: Sex determination Region on the Y chromosome

4 Sufficiency： transgenic

5 表观遗传与个体发育 什么是表观遗传 与个体发育的关系 我是怎么进入表观遗传领域的 做了什么

6 遗传(genetics) and 表观遗传(epigenetics)

7 Epigenetic phenomena Polycomb and Trithorax Drosophila study Sex comb
Not determined by DNA sequence

8 B + SAM-CH3 Histones + Enzyme

9

10

11

12

13 个体发育与表观遗传

14 Imprinted genes

15 Imprinting: allelic specific silencing

16 The Problem: Dosage difference X/Y contain different number of genes

17 When is X-chromosome inactivated?

18 Epigenetic regulation of X inactivation

19 Heterochromatin formation

20 Epigenetics in cancer

21 Epigenetics with iPS

22 表观遗传

23 遗传信息：可遗传的DNA系列 表观遗传信息：可遗传的非DNA系列信息 DNA修饰（甲基化） 非编码RNA 组蛋白修饰（甲基化等） 染色体重塑

24 DNA不变 如何形成各种细胞, 且每种细胞保持其遗传性?

25 Nature Mar 18

26

27 Histone marked enhancers are cell type specific

28 Expression of cell-type specific genes
associates with specific enhancers

29

30

31

32 Life cycle of C. elegans

33 Progressive reduction of brood size in spr-5 ko

34 Percentage of sterile animals

35 H3K4me2 retention in mutant animals

36 Spr-5 regulated oogenesis and spermatogenesis

37 Outcross abolished epigenetic memory

38 我怎么进入表观遗传学领域的?