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第十章 Bioenergetics: How Do Organisms Acquire and Use Energy 前言.

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Presentation on theme: "第十章 Bioenergetics: How Do Organisms Acquire and Use Energy 前言."— Presentation transcript:

1 第十章 Bioenergetics: How Do Organisms Acquire and Use Energy 前言

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3 How does Energy Behave in the Universe

4 How is Energy Transformed in the Biosphere

5 Metabolism is both Efficient and Highly Specific

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7 脢的結構與功能 脢的四個特徵: 脢只是使反應加速而已 脢可以重複使用 脢催化正反方向的反應 脢有基質特異性

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10 脢與基質的交互作用 鎖與鑰匙模式(Key and lock model) 誘導與適合模式 (Induced-fit model)

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12 影響脢活動的因子 脢與環境的關係 回饋反應

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17 ATP—細胞能量的流通 Cells “earn” ATP in exergonic reactions
Cells “spend” ATP in endergonic reactions

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22 How Do Organisms use Energy

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25 細胞如何製造ATP 能量釋放途徑主要型式之比較 有氧呼吸的總覽

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29 醣解作用(Glycolysis): 能量釋放途徑的第 一階段

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36 有氧呼吸的第二階段

37 pyruvate + coenzyme A + NAD+
有氧呼吸的第二階段 前置步驟和Kreb循環 pyruvate + coenzyme A + NAD+ acetyl-CoA + NADH + CO2 One of the carbons from pyruvate is released in CO2 Two carbons are attached to coenzyme A and continue on to the Krebs cycle

38 What is Acetyl-CoA? A two-carbon acetyl group linked to coenzyme A
CH3 C=O Coenzyme A Acetyl group

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40 Kreb’s cycle 的特徵 1.電子與氫裝載在NAD+與FAD上, 產生6個NADH與2個FADH2. 2.進行受質層次磷酸化產生2個ATP. 3.重新產生草醋酸使循環得以再進行.

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42 Coenzyme Reductions During First Two Stages
Glycolysis NADH Preparatory reactions NADH Krebs cycle FADH NADH Total FADH NADH

43 有氧呼吸的第三階段

44 電子傳遞磷酸化作用 (Electron Transport Phosphorylation)
Occurs in the mitochondria Coenzymes deliver electrons to electron transport systems Electron transport sets up H+ ion gradients Flow of H+ down gradients powers ATP formation

45 Electron Transport Electron transport systems are embedded in inner mitochondrial compartment NADH and FADH2 give up electrons that they picked up in earlier stages to electron transport system Electrons are transported through the system The final electron acceptor is oxygen

46 Creating an H+ Gradient
OUTER COMPARTMENT NADH INNER COMPARTMENT

47 Making ATP: Chemiosmotic Model
INNER COMPARTMENT ADP + Pi

48 (per molecule of glucose)
能量報酬之摘要 (per molecule of glucose) Glycolysis 2 ATP formed by substrate-level phosphorylation Krebs cycle and preparatory reactions Electron transport phosphorylation 32 ATP formed

49 Energy Harvest from Coenzyme Reductions
What are the sources of electrons used to generate the 32 ATP in the final stage? 4 ATP - generated using electrons released during glycolysis and carried by NADH 28 ATP - generated using electrons formed during second-stage reactions and carried by NADH and FADH2

50 Energy Harvest Varies NADH formed in cytoplasm cannot enter mitochondrion It delivers electrons to mitochondrial membrane Membrane proteins shuttle electrons to NAD+ or FAD inside mitochondrion Electrons given to FAD yield less ATP than those given to NAD+

51 Energy Harvest Varies Skeletal muscle and brain cells
Liver, kidney, heart cells Electrons from first-stage reactions are delivered to NAD+ in mitochondria Total energy harvest is 38 ATP Skeletal muscle and brain cells Electrons from first-stage reactions are delivered to FAD in mitochondria Total energy harvest is 36 ATP

52 Efficiency of Aerobic Respiration
686 kcal of energy are released 7.5 kcal are conserved in each ATP When 36 ATP form, 270 kcal (36 X 7.5) are captured in ATP Efficiency is 270 / 686 X 100 = 39 percent Most energy is lost as heat

53 ATP形成途徑 發酵作用途徑 乳酸發酵 酒精發酵 無氧電子傳遞

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55 electrons, hydrogen from NADH
GLYCOLYSIS C6H12O6 2 ATP energy input 2 ADP 2 NAD+ 2 NADH 4 ATP energy output 2 pyruvate 2 ATP net ETHANOL FORMATION 2 H2O 2 CO2 2 acetaldehyde electrons, hydrogen from NADH Fig. 7.10, p. 119 2 ethanol

56 Carbohydrate Breakdown and Storage
Glucose is absorbed into blood Pancreas releases insulin Insulin stimulates glucose uptake by cells Cells convert glucose to glucose-6-phosphate This traps glucose in cytoplasm where it can be used for glycolysis

57 Energy Reserves Glycogen makes up only about 1 percent of the body’s energy reserves Proteins make up 21 percent of energy reserves Fat makes up the bulk of reserves (78 percent)

58 Making Glycogen If glucose intake is high, ATP-making machinery goes into high gear When ATP levels rise high enough, glucose-6-phosphate is diverted into glycogen synthesis (mainly in liver and muscle) Glycogen is the main storage polysaccharide in animals

59 Using Glycogen When blood levels of glucose decline, pancreas releases glucagon Glucagon stimulates liver cells to convert glycogen back to glucose and to release it to the blood (Muscle cells do not release their stored glycogen)

60 Energy from Fats Most stored fats are triglycerides
Triglycerides are broken down to glycerol and fatty acids Glycerol is converted to PGAL, an intermediate of glycolysis Fatty acids are broken down and converted to acetyl-CoA, which enters Krebs cycle

61 Energy from Proteins Proteins are broken down to amino acids
Amino acids are broken apart Amino group is removed, ammonia forms, is converted to urea and excreted Carbon backbones can enter the Krebs cycle or its preparatory reactions

62 Processes Are Linked Aerobic Respiration Photosynthesis Reactants
Sugar Oxygen Products Carbon dioxide Water Photosynthesis Reactants Carbon dioxide Water Products Sugar Oxygen

63 How Do Organisms Acquire Energy
前言 自營生物(Autotrophs) 光自營生物 (Photoautotrophs) 異營生物(Heterotrophs)

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67 光合作用的綜觀 反應發生的位置 反應的能量與物質

68 12H2O + 6CO2 6O2 + C2H12O6 + 6H2O LIGHT ENERGY WATER CARBON DIOXIDE
OXYGEN GLUCOSE WATER in-text, p. 93

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73 陽光是能量的來源 彩虹的捕捉者 為什麼不是所有的色素都是黑色

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89 碳的固定 C3植物 C4植物 CAM植物

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94 深海火山口的自營生物 自營生物與生物圈

95 冬天時的光合作用力 (太平洋)

96 春天時的光合作用力 (太平洋)

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