Paper Survey Nanomaterial-enhanced paper-based biosensors Trends in Analytical Chemistry 58 (2014) 31–39 Nanomaterial-enhanced paper-based biosensors Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, PR China Chemistry Department, King Abdulaziz University, Jeddah 21589, Saudi Arabia School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164, USA College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, PR China Paper Survey Xiaoxiao Ge , Abdullah Mohamed Asiri , Dan Dua, Wei Wen, Shengfu Wang , Yuehe Lin Advisor : Cheng-Hsin Chuang Advisee ﹕Ting-Chi Huang Date ﹕2015/03/06
Outline Paper Survey Future Work Nano particle-based lateral-flow test-strip devices Summary of nano materials used in LFTS biosensors Electrochemical detection Colorimetric detection NP-based paper microfluidic biosensor Conclusion Future Work
lateral-flow test-strip devices Nano particle-based lateral-flow test-strip devices Fig. 1. The scheme of a lateral-flow test-strip (LFTS) immunosensor.
Summary of nano materials used in LFTS biosensors 電化學測定法 探測器小，價格便宜，需要基板 可量測到多種類的信號 但有時候會量測不到有特異性的信號 比色法 需要一個可攜式條狀的讀取器 跟一個紫外/可見分光光度計 光學檢測器通常都比電化學檢測器昂貴 信號通常以量子點表示 螢光檢測法 需要磁力測定器，噪音低 信號可長時間保持穩定 磁力檢測法
Electrochemical detection Fig. 2. (A) Entire portable analytical system. (B) lateral-flow test-strip (LFTS) device. (C) The principle of the LFTS device.
Colorimetric detection 纖維素薄膜 黏著層 以DNA當作鍵結 增強訊號的介質 Fig. 3. Principle of the conventional and enhanced test-strip biosensors.
NP-based paper microfluidic biosensor 蠟印 碳墨 折線 表面沉積 加入探針 Fig. 5. (A) Fabrication of paper biosensor and (B) paper-based biosensing device for detection of analytes.
Conclusion Most NP-based microfluidic devices developed so far were fabricated from polymer. The NP-based LFTSs and paper microfluidic biosensors show numerous benefits and great potential over conventional bioanalysis, such as portability, low cost, rapid response, and excellent selectivity and sensitivity.
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