Dr. Qiong Yuan SciFinder产品拓展经理 CAS用户会 2010年11月3-5日

议程 SciFinder产品开发 案例研究 即将添加的新功能 其它信息 Q&A April 16, 2019 CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.

SciFinder是科学研究的首选工具 有基于Web的直观界面 April 16, 2019 SciFinder是科学研究的首选工具 有基于Web的直观界面 支持常用英语表达-如， “I am interested in the milk production of cows” 建立了绘画结构式的工具 检索所有主要的CAS数据库 被世界上所有主要的化学和制药公司使用 CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.

SciFinder最初的开发团队 April 16, 2019 CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.

现在的SciFinder开发团队 April 16, 2019 CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.

根据用户的使用经验进行产品改进是非常重要的 April 16, 2019 根据用户的使用经验进行产品改进是非常重要的 显示结果 用户界面 查找信息 处理结果集 后处理 内容 CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.

April 16, 2019 创建数据库的科学家们 CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.

CAS分析全球化学信息，其中亚洲一些重要出版物也包含在内 April 16, 2019 CAS分析全球化学信息，其中亚洲一些重要出版物也包含在内 每年, CAS涵盖 10,000 种期刊和世界上61个授权机构的专利 2,068 种亚洲期刊 所有主要亚洲授权机构的专利，包括 中华人民共和国 韩国 日本 印度 CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.

CAS Patents Covered Each Year April 16, 2019 世界范围内新的化学专利持续增长... CAS Patents Covered Each Year Year CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved. 9 9

Chemistry Patent Applications Published 1999-2009 April 16, 2019 ...包括中文化学研究专利 Chemistry Patent Applications Published 1999-2009 China (SIPO) Japan (JPO) United States (USPTO) 80000 70000 60000 50000 Documents in CAS Databases 40000 30000 Projected, based on January-June 2010 20000 10000 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 Year CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.

SciFinder 是唯一一个支持企业全程研发需求的研究工具 April 16, 2019 SciFinder 是唯一一个支持企业全程研发需求的研究工具 Pre-clinical – “Discovery” Target Discovery Lead Discovery Lead Optimization ADMET assay development screening drug design pharmacokinetics bioavailability systemic exposure Many compounds, many data sources Lot of manual work to create profiles and documentation-beside experimental data, scientific information is crucial Wrong decisions are very costly disease models target identification target validation medicinal chemistry rational drug design structure activity relationships CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.

我们来检索关于老年痴呆症的最新研究 April 16, 2019 CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.

April 16, 2019 从感兴趣的主结构检索开始 CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.

SciFinder给出了CAS登记号338747-41-4的界面，并显示其有12篇文献 April 16, 2019 SciFinder给出了CAS登记号338747-41-4的界面，并显示其有12篇文献 CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.

April 16, 2019 其中还包括了3篇专利 CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.

April 16, 2019 亚结构检索得到了55个结果 CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.

点击Get Reference后，其显示有14篇是与生物研究相关的结果，其中包含了6篇专利 April 16, 2019 X CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.

April 16, 2019 我们仔细查看第二篇专利中的详细内容 I am highlighting one of the hits from my substructure search, which contains the substructure of interest. CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.

进行Markush检索以进一步探究专利保护范围 April 16, 2019 进行Markush检索以进一步探究专利保护范围 CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.

SciFinder有许多检索这个先导化合物合成方法的强大功能 April 16, 2019 SciFinder有许多检索这个先导化合物合成方法的强大功能 CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.

Get Similar Reactions为相同化学变化提供了可供选择的合成路径 April 16, 2019 Get Similar Reactions为相同化学变化提供了可供选择的合成路径 CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.

设置Keep Me Posted 能够使您自动获取您感兴趣主题的最新信息 April 16, 2019 CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.

改进的Keep Me Posted 功能使您能容易地获取到感兴趣的文献 April 16, 2019 改进的Keep Me Posted 功能使您能容易地获取到感兴趣的文献 : KMP alerts now deliver up to first 5 results in email, and titles are hyperlinked to easily get to your references of interest Last things I would like to talk about are Keep Me Posted alerts. The KMP alert emails you receive are now more informative. They contain up to 5 hyperlinks of the article titles or substance links. If you follow the hyperlink you are taken to the login page first and then to the actual links. Potential questions Why only 5? Feedback we have received has suggested that our users usually look at a small number of answer by quickly browsing through the answer set, and that they care about recent articles. Depending on the feedback we will receive in the future this number might change to 10 or other number. How do you select which 5? These are the most recent 5 articles. How do I get to the answers that are not part of the 5? You follow any of the hyperlinked titles and you’ll get to your answer set. CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.

围绕该先导化合物，我们可以进一步探索其保护范围 April 16, 2019 围绕该先导化合物，我们可以进一步探索其保护范围 CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.

只有在Web版上才能获取到CAS持续改进的SciFinder功能和内容 April 16, 2019 只有在Web版上才能获取到CAS持续改进的SciFinder功能和内容 CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.

即将添加的新功能 SMILES/InChI 实验步骤 改进的反应显示格式 反应相关性排列 来自ACS期刊的专利链接 April 16, 2019 即将添加的新功能 SMILES/InChI 实验步骤 改进的反应显示格式 反应相关性排列 来自ACS期刊的专利链接 CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.

使用SMILES和InChi strings建立结构式 April 16, 2019 使用SMILES和InChi strings建立结构式 CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.

然后使用这些结构式进行反应检索 April 16, 2019 CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.

April 16, 2019 新功能增强了结构式的可视性 CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.

April 16, 2019 用实验步骤方便地整理答案集 CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.

April 16, 2019 可以显示和分析实验步骤 CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.

以相关性排列顺序显示反应检索结果 排序标准： 产物相似性 (Tanimoto) 反应物相似性 (Tanimoto) 仍可以使用登记号进行排序 April 16, 2019 以相关性排列顺序显示反应检索结果 排序标准： 产物相似性 (Tanimoto) 反应物相似性 (Tanimoto) 仍可以使用登记号进行排序 CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.

April 16, 2019 计划加入ACS期刊链接的功能 CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.

April 16, 2019 优秀的销售和支持团队 A part of our shared future is the new CAS web site designed specifically for the Chinese user. When you get a chance, visit the site, look around, and let us know what you think about it! (Last slide before thank you….) CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.

去年CAS为中国用户开发了中文网站 www.cas-china.org April 16, 2019 去年CAS为中国用户开发了中文网站 A part of our shared future is the new CAS web site designed specifically for the Chinese user. When you get a chance, visit the site, look around, and let us know what you think about it! (Last slide before thank you….) www.cas-china.org CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.

April 16, 2019 谢谢! CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.