肿瘤靶向 药物控释 基于大分子的 Polymeric Tumor-Targeting Drug Controlled Release

Presentation on theme: "肿瘤靶向 药物控释 基于大分子的 Polymeric Tumor-Targeting Drug Controlled Release"— Presentation transcript:

1 肿瘤靶向 药物控释 基于大分子的 Polymeric Tumor-Targeting Drug Controlled Release
【般若黑洞】出品 Northwestern Polytechnic University

2 Drug Load 装载 Drug Release 释放 定位 Targeting

3 装载 树枝状聚合物 胶束 聚合物-药物 偶联物 微脂囊 Dendrimers Micelles Drug Load Polymer-drug
conjugates Liposomes 微脂囊

4 定位 配合基-受体 主动 被动 EPR效应 叶酸 active Ligand-receptor cRGD Targeting passive
EPR Effect

5 正常组织 癌变部位

6 释放 外因 内因 磁场 pH UV 温度 电场 降解 -s-s- PDEAEMA PNIPAM hydrazone bonds
Drug Release 释放 UV 温度 PNIPAM 电场 降解 -s-s-

7 点击化学 超分子 星形 RAFT 端基 嵌段 分子设计 Molecular Design 开环 分子量 多层 ATRP

8 Xiang Lan Wu, Jong Ho Kim Tumor-Targeting Peptide Conjugated pH-Responsive Micelles as a Potential Drug Carrier for Cancer Therapy

9 Xiaoqiang Yang, Jamison J. Grailer, Srikanth Pilla
Tumor-Targeting, pH-Responsive, and Stable Unimolecular Micelles as Drug Nanocarriers for Targeted Cancer Therapy

10 Xiang Lan Wu, Jong Ho Kim PEG-SS-PPS: Reduction-Sensitive Disulfide Block Copolymer Vesicles for Intracellular Drug Delivery

11 Priyadarsi De, Sudershan R. Gondi, and Brent S. Sumerlin
Folate-Conjugated Thermoresponsive Block Copolymers: Highly Efficient Conjugation and Solution Self-Assembly

12 Bhanuprasanth Koppolu, MS, Maham Rahim,
Development of multiple-layer polymeric particles for targeted and controlled drug delivery

13 Thermo-Responsive Hyperbranched poly(β-CD)s-g-PNIPAM
2 β-CD based HBP Core grafted PNIPAM Shell Thermo-Responsive Hyperbranched poly(β-CD)s-g-PNIPAM

14 Thank you! Polymeric Tumor-Targeting Drug Controlled Release
Northwestern Polytechnic University