Acute Pancreatitis XUE Huiping Acute Pancreatitis XUE Huiping.

Slides:



Advertisements
Similar presentations
心肺脑复苏 Cardiopulmonary Cerebral Resuscitation , CPCR.
Advertisements

急、慢性腎衰竭 盧亞人醫院 護理師 林伊柔. Renal function 簡介 Remove nitrogenous, toxic waste products (主要為尿素、尿酸、肌酸酐) Regulate fluid, electrolyte Acid-base balance 調整血壓:經由腎素體系進行調節。
、休克的概念 2 、休克的原因和分类 5 、休克的防治原则 1 、休克的概念 3 、休克的微循环改变及发生机制 4 、休克时机体机能和代谢改变.
急腹症 acute abdomen. 概念 是一类以急性腹痛为突出表现的腹部 疾病的总称 消化系统 — 炎症、穿孔、梗阻等 泌尿系统 — 炎症、结石等 生殖系统 — 宫外孕等 循环系统 — 腹主动脉疾病等.
BASIC PRINCIPLES IN OCCUPATIONAL HYGIENE 职业卫生基本原则 Day 2 第 2 天.
中国急性胰腺炎诊治指南 2013 版解读 胡益群 胡益群. 1.Classification of acute pancreatitis—2012: revision of the Atlanta classification and definitions by international consensus.
弥散性血管内凝血 Disseminated Intravascular Coagulation (DIC) 病理生理学系 Department of Pathophysiology 高远生.
甲状腺疾病的实验室检查 安徽省立医院 陈 燕. 方法与原理 甲状腺功能测定 甲状腺自身免疫抗体测定 甲状腺球蛋白测定 降钙素测定.
第十一章 泌尿系统疾病 病理学教研室 李菊英. Content 肾脏结构与生理 肾小球肾炎 肾盂肾炎.
昏 迷 coma 沈燕 2006-4-20.
欢迎大家学习病理生理学! 希望大家努力学好病理生理学!.
認識粥狀動脈栓塞 長庚紀念醫院林口總院 心臟內科張其任醫師.
Diseases of Biliary tract
原 发 性 高 血 压 ( Primary Hypertension ) 河南中医学院第一附属医院 杜正光
(Rickets of Vitamin D deficiency)
急性肾衰竭 (Acute renal failure, ARF)
上海第二医科大学 附属瑞金临床医学院检验系 洪秀华 卫蓓文
脊髓灰质炎 Poliomyelitis.
Shanghai University of Traditional Chinese medicine
慢性鼻竇炎病人趨化激素RANTES, Eotaxin與疾病嚴重度的相關性
尿液检验 urinalysis.
卵巢过度刺激综合征 ( ovarian hyperstimulation syndrome, OHSS)
胎盘早剥 汪希鹏.
异 位 妊 娠 Ectopic Pregnancy
男性乳腺癌治疗进展 杨 默 芜湖市中医医院肿瘤科.
Blast Injury.
第四章 體液代謝與血行力學障礙(Disturbance of Body Fluid and Hemodynamics)
指侵犯人体肝细胞为主,并引起肝炎的病毒,有甲、乙、丙、丁、戊等种类
溃疡性结肠炎(Ulcerative Colitis) And克罗恩病(Crohn's disease,Crohn病,CD)
急性胰腺炎 Acute pancreatitis,AP [əˈkju:t ,pæŋkriə'taitis]
黄疸的诊断和治疗.
黄 热 病 YELLOW FEVER 上海出入境检验检疫局
What`s abortion? Abortion is termination of pregnancy before 28 weeks of gestation and the fetal weight is less than 1000g. 流产是指 妊娠不足28周、胎儿体重不足1000g而终止者。
泌尿系统 urinary system 肾 输尿管 膀胱 尿道
(Kalemia disturbance)
低钾血症(hypokalemia) 外科教研室 曾守静
静脉输液(intravenous infusion)是利用液体静压的原理,将一定量灭菌药液直接滴入静脉内的治疗方法。
B型肝炎帶原之肝細胞癌患者接受肝動脈栓塞治療後血液中DNA之定量分析
社會科評量命題之考量 嘉義大學 家庭教育與諮商研究所 張再明.
水飛薊 (Silymarin)對高血糖症之影響
分析抗焦慮劑/安眠劑之使用的影響因子在重度憂鬱症及廣泛性焦慮症病人和一般大眾的處方形態
神经病学 — 头痛 (Headache) 哈尔滨医科大学附属第二医院 神经病学教研室.
TUBERCULOSIS.
Unit 19 Heart Failure 心力衰竭 韩明华.
Congenital Malrotation of Midgut – A Case Report 先天性中腸扭轉案例報告
第五章 结膜病 Disorder of the conjunction
動脈化學灌注治療 IntraAterial Infusion Chemotherapy
Epidemic encephalitis B
Elderly Suicide in Hong Kong 香港長者的自殺状况研究
病歷書寫的方向與重點 蘇育敏.
Amazing Gingers 神奇的生薑 Ginger contains anti viral, anti toxic, and anti fungal properties, and is used for the prevention of and treatment against the.
重症病童輸液問題之處置與照護 成大小兒部 王玠能醫師.
Primary Mediastinal Tumor
概 述 由多种病因引起的、以慢性高血糖为特征的代谢性疾病。由于胰岛素分泌或/和作用缺陷(胰岛素抵抗),导致碳水化合物、蛋白质、脂肪、水、电解质等代谢异常 急性并发症 慢性并发症.
102/01/30 Instructor:黃允中 PGY 周裕勝
Amazing Gingers 神奇的生薑 Ginger contains anti viral, anti toxic, and anti fungal properties, and is used for the prevention of and treatment against the.
主页: 骆严 Yan LUO 主页: 手机: 浙江大学基础医学院 浙江大学肿瘤研究所.
Ultrasound of Digestive System
肠梗阻 Bowel obstruction 邵逸夫医院 王观宇.
大內科部ICU重症加護單位 品質提升計畫 內科 高國晉 副部長
肝功能不全 王婧婧 山东大学医学院病理生理学教研室.
Amazing Gingers 神奇的生薑 Ginger contains anti viral, anti toxic, and anti fungal properties, and is used for the prevention of and treatment against the.
Amazing Gingers 神奇的生薑 Ginger contains anti viral, anti toxic, and anti fungal properties, and is used for the prevention of and treatment against the.
口病實驗平時考試 (7) 姓名 學號 日期 組別.
消化系统影像学.
Amazing Gingers 神奇的生薑 Ginger contains anti viral, anti toxic, and anti fungal properties, and is used for the prevention of and treatment against the.
Amazing Gingers 神奇的生薑 Ginger contains anti viral, anti toxic, and anti fungal properties, and is used for the prevention of and treatment against the.
口病實驗平時考試 (12) 姓名 學號 日期 組別.
SHPT:挑战与策略 张 凌 武汉.
Presentation transcript:

Acute Pancreatitis XUE Huiping Acute Pancreatitis XUE Huiping

Pancreatitis is an inflammatory process in which pancreatic enzymes autodigest the gland.

√The gland can sometimes heal without any impairment of function or any morphologic changes. This process is known as acute pancreatitis. √It can recur intermittently, contributing to the functional and morphologic loss of the gland, the pathological change referred to as chronic pancreatitis.

√Acute pancreatitis refers to an attack involving a previously normal pancrease. √Chronic pancreatis is applied to an attack involving a previously, permanently damaged pancrease.

√ Acute pancreatitis is an acute inflammatory process of the pancreas, with variable involvement of other regional tissue or remote organ systems. √ Although pancreatic function and structure usually return to normal, the risk of recurrent attacks is 20 to 50% unless the precipitating cause is removed. √ The disease includes a broad spectrum of pancreatic disease, which varies from mild parenchymal edema to severe hemorrhagic pancreatitis associated with subsequent gangrene and necrosis. 急性胰腺炎( acute pancreatitis )是指胰酶在胰腺内激活 后引起胰腺组织自身消化的急性化学性炎症。

A sensible classification system separates pancreatitis into mild and severe disease based on physiologic findings, laboratory values, and radiologic imaging.

Mild pancreatitis is not associated with organ dysfunction or complications, and recovery is uneventful. Severe pancreatitis is associated with decreased function of the pancreas, local and systemic complications, and a complicated recovery.

√ 轻型急性胰腺炎是指仅有很轻微的 脏器功能紊乱,没有明显腹膜炎体征 及严重代谢紊乱等临床表现,临床恢 复顺利者。该型病理上绝大多数为水 肿型胰腺炎,少数也可有胰腺实质坏 死。

Severe pancreatitis is defined as a local complication and/or organ failure.

√ 重症急性胰腺炎是指急性胰腺炎 伴有脏器功能障碍,或出现坏死、 脓肿或假性囊肿等局部并发症, 或两者兼有。该型病理上绝大多 数为坏死型胰腺炎,但少数情况 下水肿型胰腺炎也可表现为重症 胰腺炎。

Local complications are defined as (1) acute fluid collections; (2) pancreatic necrosis; (3) pancreatic abscess; (4) pancreatic pseudosyst

√ The clinical presentation of acute pancreatitis is variable, from episodes of mild abdominal discomfort alone to a severe illness associated with hypotension, metabolic derangements, sepsis, fluid sequenstration, multiple organ failure or even death. √ It is always accompanied by an increased concentrations of pancreatic enzymes in blood and in urine.

Etiology Approximately 70-80% of patients either have gallstones or a history of sustained alcohol abuse. Etiology Approximately 70-80% of patients either have gallstones or a history of sustained alcohol abuse.

√Choledocholithiasis( 胆总管石 病 ) and ethanol abuse account for 70 to 80% of all cases.

√ Gallstones may cause pancreatitis by impacting in the ampulla of Vater. √ The incidence of gallstone- associated pancreatitis parallels that of cholelithiasis( 胆石症 ): it peaks at ages 50 to 70, and women outnumber men by 2 to 1.

Causes of Acute Pancreatitis Obstruction: Biliary tract disease: cholelithiasis, tumor, ascarid, stenosis pancreatic duct obstruction: neoplasms, cysts,pancreas divisum annular pancreas ampullary stenosis, duodenal diverticulum Duodenal obstruction Alcohol Hyperlipidemia Hypercalcemia Hereditary Trauma:external, operative,ERCP Ischemia:hypotension,cardiopulmonary bypass, atheroembolism,vasculitis Infectious causes: parastic bacterial viral fungal Drugs:steroids,azathioprine 6-mercaptopurine, Idiopathic

Obstructive Causes Choledocholithiasis 胆总管石病 Ampullary obstruction by tumor or sphincter of Oddi hypertension Choledochocele 胆总管囊肿 Periampullary duodenal diverticulum( 憩室 ) Pancreas divisum : annular( 环状的 ) pancreas Primary or metastatic pancreatic tumor Parasites in pancreatic duct: Clonorchis( 支睾吸虫 ), Ascaris

Drugs azathioprine 硫唑嘌呤 /6-mercaptopurine6- 巯基 嘌呤 ; valproic acid 丙戊酸 ; estrogens 雌激素 ; metronidazole 灭滴灵,甲硝唑 ; loop diuretics, including thiazides 噻嗪类, furosemide 速尿 ; pentamidine; sulfonamides, including sulfasalazine; methyldopa: L-asparaginase; tetracyclines, etc.

Pathogenesis 1.A complicated pathophysiologic process 2.Enzyme autoactivation and self-digestion (key point) 3. Many agents participating in the process 4. Complete mechanism remaining unknown

Pancreatic self-protective mechanism 1.mucopolysaccharide on pancreatic duct epithelia 2.proenzyme 3.pancreatin inhibitor 4.acinus metabolism activity 5. Anti-reflux mechanism: oddi’s sphincter pancreatic duct sphincter

Initiation factor in Earlier period

1. Pancreatic Enzyme Abnormally Activated ⑴ Bile reflux Bile common channel pancreatic duct 1.hypertension in pancreatic duct 2.premature activation of pancreatic enzymes 3.injury to the lining of the pancreatic ducts pancreatic edema or necrosis MODS

⑵ Duodenal Refulx duodenal enterokinase pancreatic duct trypsinogen trypsin elastasnogen elastase phospholipasogen phospholipase lecithin lysolecthin

2.Alcohol Toxicity ⑴ stimulate the pancreas to secrete pancreatic hypertention tiny pancreatic duct and acinus rupture pancreatic juice spillage ⑵ spasm of the sphinctor of oddi ⑶ direct injury to pancreas

3.Pancreatic Microcirculation Disorder ⑴ systemic hypotension ⑵ hyperlipidemia: triglycerides lipase free acid fatty acids injure pancreatic microcirculation ⑶ artheroembolism ⑷ vasculitis

Aggravatiing factors in later period ⑴ Infection: pancreatic abscess ⑵ Intestinal bacteria translocation ⑶ Cytokine and systemic inflammation reaction syndrome TNF IL-1 IL-6 PAF MSOF ⑷ Free radicals

PATHOGENESIS Premature activation of zymogens( 酶 原 ) and the escape of activated enzymes from acinar cells and pancreatic ducts set the stage for the autodigestive process that represents acute pancreatitis.

PATHOGENESIS Proteases( 蛋白酶 ) released into the blood are inactivated by circulating inhibitors, including α 2 - macroglobulin( 巨球蛋白 ). α 1 - antitrypsin( 抗胰蛋白酶 ), and the C 1 - esterase( 酯酶 ) inhibitor.

In addition, trypsin( 胰蛋白酶 ) activates kallikrein( 激肽释放酶 ), a peptidase( 肽酶 ), which then cleaves several peptides, including bradykinin( 缓激肽 ) and kallidin( 胰 激肽 ), from their inactive precursors in blood plasma. PATHOGENESIS

These peptides, termed kinins( 激 肽 ), have various deleterious effects including vasodilatation, increased vascular permeability, pain, and neutrophil( 嗜中性粒细 胞 ) accumulation.

Two mechanisms may trigger pancreatic autodigestion zymogen activation within the pancreatic acinar cell. increased pancreatic duct permeability

PATHOGENESIS After the acinar cell is triggered, it provokes an intense inflammatory response in the pancreas. Weeping of pancreatic juice into the peripancreatic space or microperforations of the pancreatic ductal system can lead to pseudocyst formation.

PATHOGENESIS Subsequent hypoperfusion to the gland can convert mild edematous/interstitial pancreatitis to necrotizing pancreatitis. At this point, release of toxic factors into the systemic circulation, such as trypsin, elastase, phospholipase A2, and platelet activating factor or other cytokines, can lead to cardiovascular and pulmonary collapse. The necrotic pancreas can become secondarily infected from hematogenous or transperitoneal sources.

重症胰腺炎是一多因素、累及多环节 的疾病。首先是几种致病因素引发胰 腺腺泡的损伤,释放多种受激活的胰 酶及炎症细胞因子,有多种细胞的过 度激活和相互作用,产生氧自由基和 炎症介质引起胰腺、腹膜和一些主要 器官 ( 肺、脑 ) 的血管通透性增加,最 后导致了重症胰腺炎及其并发症的发 生。

Pathology 1.Edematous pancreatitis: *interstitial edema *inflammatory cell infiltration of the gland parenchyma 2.Hemorrhagic or necrotizing pancreatitis *extensive pancreatic and peripancreatic fat necrosis *parenchymal necrosis

Overview of the pancreatic gland The pancreatic gland contains three major types of cells. The duct cells make up about 10% of the pancreas and secrete solutions rich in bicarbonate. The acinar cells comprise over 80% of the pancreas and they synthesize and secrete pancreatic enzymes.

Overview of the pancreatic gland The islet cells make up about 10% of the pancreas and form the endocrine portion of the pancreas. The four major types of islet cells secrete the hormones insulin, glucagon, somatostatin, and pancreatic polypeptide.

Interstitial The gross architecture of the gland is preserved, but it is edematous. Hemorrhage is absent. Interstitial edema and inflammatory cells within the parenchyma are prominent. Disruption of the normal acinar cell architecture is common and may contribute to characteristically reduced enzyme secretion.

Interstitial edema and inflammatory cells within the parenchyma

Hemorrhagic Macroscopically, marked tissue necrosis and hemorrhage are apparent. Surrounding areas of fat necrosis are also prominent. These are chalky 白垩的 areas of dead adipose tissue that are found within the peripancreatic tissue and throughout the abdomen. Large hematomas 血肿 often are located in the retroperitoneal 腹膜后的 space.

Hemorrhagic The microscopic appearance of the pancreas parallels the gross changes, with marked fat and pancreatic necrosis. Vascular inflammation and thrombosis are common.

Fat necrosis Fat necrosis seen at surgery is associated with peripancreatic release of lipase, with hydrolysis of triacylglycerols (triglycerides) to toxic fatty acids.

Clinical Presentation Steady, dull, or boring midepigastric pain associated with nausea and vomiting is the classic presentation of acute pancreatitis.

Abdominal pain predominant clinical featurepredominant clinical feature midepigastrium, in the right or left upper quadrantsmidepigastrium, in the right or left upper quadrants The pain reaches peak intensity within 15 minutes to 1 hour from onset, in contrast to the more abrupt onset of pain with a perforated viscus.The pain reaches peak intensity within 15 minutes to 1 hour from onset, in contrast to the more abrupt onset of pain with a perforated viscus. a penetrating pain, radiating to the back (a penetrating pain, radiating to the back ( It radiates straight to the midline of the lower thoracic vertebral region in about 50% of patients and is usually worse in the supine position.)

Abdominal pain rare patients without abdominal pain but with a severe systemic illness ( hypotension, hypoperfusion and depression of mental status) ----rare patients without abdominal pain but with a severe systemic illness ( hypotension, hypoperfusion and depression of mental status) ---- Painless acute pancreatitis is very rare but carries a grave prognosis because the patients frequently present in shock.

Clinical Presentation Nausea and vomitingNausea and vomiting Abdominal Distention resulting from a paralytic ileus arising from retroperitoneal irritation or ascites or a retroperitoneal phlegmonAbdominal Distention resulting from a paralytic ileus arising from retroperitoneal irritation or ascites or a retroperitoneal phlegmon Jaundice distal common bile duct obstruction by gallstones’ compression of the distal CBD by pancreatic head edema or by other uncommon findingsJaundice distal common bile duct obstruction by gallstones’ compression of the distal CBD by pancreatic head edema or by other uncommon findings

Abdominal Distention Paralytic ileus( 麻痹性肠梗阻 ) with abdominal distention may develop during the first few days, signifying extension of the inflammatory process into the small intestinal and colonic( 结肠的 ) mesentery( 肠系膜 ).

Clinical Presentation of Sever Pancreatitis Circulatory Derangements: hypotention, hypovolemia, hypoeffusion ⑴ circulating myocardial depressant factorCirculatory Derangements: hypotention, hypovolemia, hypoeffusion ⑴ circulating myocardial depressant factor ⑵ decreased preload to the heart ⑶ reduced systemic vascular resistance ⑷ sepsis-like syndrome hyperdynamic state elevated cardiac output lowered systemic vascular resistance lowered arteriovenous oxgen difference ⑵ decreased preload to the heart ⑶ reduced systemic vascular resistance ⑷ sepsis-like syndrome hyperdynamic state elevated cardiac output lowered systemic vascular resistance lowered arteriovenous oxgen difference

Clinical Presentation of Sever Pancreatitis left pleural effusionleft pleural effusion pulmonary failure tachypnea, dyspnea and cyanosispulmonary failure tachypnea, dyspnea and cyanosis cerebral abnormalities belligerence, confusion, psychosis and comacerebral abnormalities belligerence, confusion, psychosis and coma Turner sign and Cullen sign a bluish color in the flanks or around the umbilicus, (representing blood dissecting to those areas from the retroperitoneum near the pancreas along fascial planes)Turner sign and Cullen sign a bluish color in the flanks or around the umbilicus, (representing blood dissecting to those areas from the retroperitoneum near the pancreas along fascial planes)

One to 2 weeks after the onset, large ecchymoses( 瘀斑 ) may appear in the flanks 侧 腹 (Grey Turner ’ s sign) or the umbilical area (Cullen ’ s sign);

Physical Examination Initial physical examination reveals mild fever and tachycardia( 心动过速 ); Hypotension is present in 30 to 40% of patients.

Physical Examination epigastria tenderness, rigidity and rebound tenderness (There is marked tenderness to deep palpation of the upper abdomen, but signs of peritoneal irritation are frequently absent.)epigastria tenderness, rigidity and rebound tenderness (There is marked tenderness to deep palpation of the upper abdomen, but signs of peritoneal irritation are frequently absent.) bowel sounds decreased or absentbowel sounds decreased or absent palpable mass swollen pancreas Pseudocyst abscesspalpable mass swollen pancreas Pseudocyst abscess

Laboratory Test

Serum Amylase Total serum amylase activity is the test most frequently used to diagnose acute pancreatitis. hyperamylasemia is observed within hrs; gradually return to normal values during the subsequent 2-5daysThe level rises 6 to 12 hours after onset of symptoms and remains elevated for 3 to 5 days in most cases. ( hyperamylasemia is observed within hrs; gradually return to normal values during the subsequent 2-5days )

Serum Amylase Values more than 3 times the upper limit of normal are highly specific for acute pancreatitis but are found in only 80 to 90% of cases. The magnitude of the rise in serum amylase does not correlate with the severity of the attack, nor does prolonged hyperamylasemia indicate developing complications. the absence of hyperamylasemia can ’ t exclude the diagnosis of acute pancreatitis (extensive pancreatic necrosis)

Disorders Associated with hyperamylasemia Intra-Abdominal Extra-Abdominal Pancreatic disorders Salivary gland disorders acute pancreatitis mumps chronic pancreatitis parotitis trauma trauma carcinoma calculi pseudocyst irradiation sialoadenitis pancreatic ascites impaired amylase excretion abscess renal failure Nonpancreatic disorders mecroamylasemia biliary tract disease Miscellaneus intestinal obstruction pneumonia mesenteric infarction pancreatic pleural effusion perforated peptic ulcer mediastinal pseudocyst peritonitis cerebral trauma afferen loop syndrome severe burns acute appendicitis diabetic reto acidosis euptured ectopic pregnancy pregnancy salpingitis drugs ruptured aortic aneurysm bisal buminemia

Urinary Amylase a sensitive index of the pancreatitisa sensitive index of the pancreatitis elevations persist for a longer period than serum amylaseelevations persist for a longer period than serum amylase some other diseases also manifest hyperamylasuriasome other diseases also manifest hyperamylasuria a normal urinary amylase can’t preclude the pancreatitisa normal urinary amylase can’t preclude the pancreatitis

Separation of total serum amylase into its pancreatic (P) and salivary (S) isoenzymes and measurements of urinary amylase output add little to the diagnostic information.

The amylase-creatinine clearance ratio (ACR) (the ratio of amylase concentration in urine over plasma, divided by the corresponding values for creatinine) is useful in diagnosing asymptomatic macroamylasemia, in which aggregates of circulating amylase escape glomerular filtration and the ACR is abnormally low.

淀粉酶 这一古老的检查方法虽已应用了半个多世纪,但对胰 腺炎的诊断仍不失为良好而简便可行的手段。由于胰 酶在胰管内逆流入血或渗出液重吸收入血,则在急性 胰腺炎时血、尿的淀粉酶有所升高。血淀粉酶正常值, 温氏单位< 256 单位,苏氏单位< 500 单位。急性胰腺 炎(轻型)发作后 6 ~ 12 小时即升高, 48 ~ 72 小时逐渐 恢复正常,尿淀粉酶约在发病后 12 ~ 24 小时升高,要 持续 3 ~ 5 天。但急性重型胰腺炎升高的时间要提前。 临床上对淀粉酶值的变化要作全面的分析,再结合临 床其他症状才能做出正确的判断。

淀粉酶 血淀粉酶值正常:有两种情况,其一表 明病已痊愈,血淀粉酶值恢复正常,同 时全身情况良好,无腹部体征。其二在 重症急性胰腺炎的初检或治疗中,淀粉 酶也可不升高,说明病情会进行性加重 恶化。因为胰腺腺泡大量坏死、崩溃, 已不能分泌淀粉酶,即所谓的 “ 枯竭 ” 现 象。这一现象在急性重症胰腺炎中时有 发生,应予以高度重视。

淀粉酶 血淀粉酶升高:有时病人出现腹痛,并伴血淀粉酶升 高,但临床的症状、体征并不支持胰腺炎,这时就应 考虑到血清淀粉酶检测往往是非特异性的。临床常见 的一些急腹症也可伴有血淀粉酶升高,如胆囊炎、胆 石症、胆道梗阻、肠梗阻、消化性溃疡病穿孔、肠系 膜血栓形成以及使用吗啡后。胆石症时可能是由于排 石对 Oddi 括约肌的刺激,使之痉挛,血淀粉酶一过性 升高。消化性溃疡穿孔(特别是十二指肠球部穿孔) 时,含有大量胰液的肠内容物进入腹腔后,淀粉酶被 腹膜吸收则血淀粉酶值升高。肠梗阻后,肠腔内肠液 淤积,淀粉酶通过受损的肠壁渗入腹腔而被吸收。因 此,对血淀粉酶的升高必须结合临床进行判断,决不 可因单纯血淀粉酶升高而诊断为胰腺炎。

淀粉酶 巨淀粉酶血症:是一罕见病症,其 原因不明,可能是由于病人血中的 淀粉酶与大分子物质形成复合物, 从而不能通过肾小球滤过,将其贮 存在血中。特点是血淀粉酶虽高, 但尿淀粉酶正常或偏低。血淀粉酶 升高可持续数月乃至数年。

淀粉酶 重症胰腺炎往往伴有腹腔大 量炎性腹水,应做腹腔穿刺 测定腹水淀粉酶,穿刺物多 为血性混浊的液体,其淀粉 酶含量可以相当高。

淀粉酶 - 肌酐肾廓清率比值( ACR ) ACCR 的正常比值为 3.8 ~ 5.3% ,若比值> 5 ~ 6% 则提示急性胰腺炎。 ACCR 在急性胰腺炎以外的疾患亦可升高(如 慢性肾衰、糖尿病酸中毒、烧伤、严重肝衰 等),因此只有在排除以上诸疾患时,才有价 值。 ACCR 一方面可用来确诊急性胰腺炎,另一方 面亦可用来排除非胰腺炎的高淀粉酶血症。 ACCR 的计算公式是: (尿淀粉酶 / 血清淀粉酶) × (血清肌酐 / 尿肌酐) ×100

Serum Lipase a more accurate indicator of acute pancreatitisa more accurate indicator of acute pancreatitis lipase is solely of pancreatic originlipase is solely of pancreatic origin The serum lipase levels tend to remain elevated longer than the amylase levels during the healing phase of pancreatitis.The serum lipase levels tend to remain elevated longer than the amylase levels during the healing phase of pancreatitis. some other diseases also manifest elevated serum lipase perforated peptic ulcer acute cholecystitis intestinal ischemiasome other diseases also manifest elevated serum lipase perforated peptic ulcer acute cholecystitis intestinal ischemia The combination of serum amylase and lipase determinations is more accurate than either test alone).The combination of serum amylase and lipase determinations is more accurate than either test alone).

Hypocalcemia the consequence of dilutional hypoalbuminemiathe consequence of dilutional hypoalbuminemia calcium desposition in areas of fat necrosiscalcium desposition in areas of fat necrosis resistance of skeletal bone to parathyroid hormone stimulationresistance of skeletal bone to parathyroid hormone stimulation The ionized calcium concentration remains normal, and symptoms of tetany( 手足抽搐 ) are extremely rare.The ionized calcium concentration remains normal, and symptoms of tetany( 手足抽搐 ) are extremely rare.

Other laboratory Test √ Elevated white cell count > cells per mm 3 Leukocytosis ( 白细胞增多 ) √ Hyperglycemia √ Mild azotemia 氮质血症 : related to fluid sequestration √ Abnormalities of liver function test

Serum triglyceride levels should be obtained in all patients because of their etiologic implications and to help interpret unexpectedly normal serum amylase and lipase levels.

Elevated alanine( 丙胺酸 ) aminotransferase( 转 氨酶 ) (ALT) and alkaline phosphatase values suggest gallstone-associated pancreatitis. The serum aspartate( 天 ( 门 ) 冬氨酸 ) aminotransferase (AST) is elevated in approximately 50% of patients, owing to alcoholic liver disease or to the pancreatic inflammation itself.

Imaging Tests 1. A plain Abdominal Film * not specific * dilatation of an isolated loop of intestine adjacent to the pancreas * calcification in the pancreas * left pleural effusions Plain films should be obtained routinely to rule out the presence of free air caused by perforation of a viscus.

2. Ultrasound Examination * no trauma * pancreatic and peripancreatic edema of fluid collection * pseudosyst * dilation of pancreatic duct * GB stone and CBD stone

Ultrasound examination showing two large pancreatic pseudocysts. Both cysts are indicated by the large white arrows.

3. CT Scans * confirm diagnosis of pancreatitis * confirm diagnosis of complications such as abscess or pseudocyst * reveal extension of inflammation and necrosis * imply prognosis * a needle aspiration under CT guide

With rapid intravenous bolus injection of contrast material, a dynamic CT scan will reveal extension of peripancreatic inflammation, involvement of adjacent organs, venous thrombosis, and fluid collections. Most importantly, pancreatic necrosis can be identified and quantitated by the lack of contrast medium enhancement after the bolus injection. The abdominal CT scan may be normal, however, in about 10% of patients with early, mild pancreatitis.

Computed Tomographic Findings in Acute pancreatitis pancreatic changes nonspecific findings parenchymal enlargement bowel distention diffuse pleural effusion focal mesenteric edema parenchymal edema necrosis peripancreatic changes blurring of fat planes thickening of fascial planes presence of fluid collections

This CT scan shows poor perfusion of the pancreas.

Abdominal Ultrasonography (US) and Computed Tomography (CT) US is the method of choice for detecting cholelithiasis( 胆石症 ) and for determining the diameter of the extrahepatic and intrahepatic bile ducts. Dilatation of these ducts suggests recent or persisting impaction of a stone in the distal common bile duct or the ampulla of Vater. When the clinical diagnosis is made, the CT scan is far superior to US for assessing the extent and local complications of pancreatitis.

Two pancreatic pseudocysts (arrows). Computed tomography following the intravenous administration of contrast material demonstrates four sharply marginated, fluid-filled collections.

Large arrow indicates inflamed pancreas. Small arrow denotes areas of peripancreatic inflammation extending toward the hilum of the spleen.

A large pseudocyst (open arrows), which is being percutaneously drained (closed arrow). Pseudocysts that develop in chronic pancreatitis are most commonly caused by duct obstruction, with the formation of a "retention" cyst in the upstream duct or side branch. Unlike the pseudocysts associated with acute pancreatitis, these pseudocysts do not contain activated enzymes, and are usually not a reflection of a necrotizing inflammatory process. These pseudocysts are less likely to produce complications than those associated with acute necrotizing pancreatitis, but they are paradoxically also less likely to resolve. Many of these pseudocysts remain asymptomatic, but they may be complicated by infection, rupture or leak, bleeding, or obstruction of a neighboring hollow viscus (eg, duodenum, bile duct, colon, or ureter, among others). Pseudocysts may also worsen chronic pain or even initiate a wasting syndrome.Recent clinical experience suggests that in patients with pseudocysts smaller than 6 cm, if there is a mature pseudocyst wall on radiographic imaging that does not resemble a cystic neoplasm, minimal symptoms, and no evidence of active alcohol abuse, the risk of complications is extremely small (< 10%). These patients may be safely observed with little risk of serious complication

Computed tomogram of a patient with pancreatic abscess. The pancreas is diffusely involved, and its margins are difficult to define because of the massive peripancreatic inflammation, which is reflected in the streaking seen in this scan. Toward the tail of the pancreas, numerous small and large bubbles are noted (arrows) in the peripancreatic inflammatory mass. Bubbles, caused by gas-forming microorganisms, indicate that the pancreatic abscess is infected.

4. Diagnostic Paracentesis 穿刺术 1. not an ideal test * an invasive procedure * complications * lack of complete specificity of peritoneal fluid enzyme elevations 2. Help diagnosis * elevations in peritoneal fluid amylase and lipase

Edematous pancreatitis nercotizing pancreatitis abdominal pain vomiting and nausea + ++ fever low high jaundice (-)-(+) psychiatric symptom no yes signs of peritonitis cullen’s sign no yes Grey Turner’s sign no yes hemorrhagic ascites no yes WBC 16000/mm 3 blood glucose normal→ ↑ > 11.1mmol/L serum calcium normal > 2.0 mmol/L amylase ↑ ↑ ↑ ↑ or (-) Pa O 2 normal 16000/mm 3 blood glucose normal→ ↑ > 11.1mmol/L serum calcium normal > 2.0 mmol/L amylase ↑ ↑ ↑ ↑ or (-) Pa O 2 normal < 8.0 kpa Bun.Cr no yes ARDS no yes DIC no yes ARF no yes mortality low high

Differential Diagnosis 1.Intestinal perforation 2.Peptic ulcer 3.Cholecystitis 4.acute intestinal obstruction 5.renal colic 6.myocardial ischemia 7.acute gastroenteritis

Treatment

Nonoperative Management 1. Dietary Control √ Oral intake is initially prohibited; √ Oral intake can be resumed during the first week of treatment when abdominal pain and tenderness have improved, ileus has resolved and hyperamylasemia is normalizing.

2. Nasogastric Suction √ reduce vomiting and abdominal distension √ reduce pancreatic exocrine secretion by reducing secretion release

3. Intravenous fluid therapy and electrolyte replacement * hypokalemia, hypochoremia, hypocalcaemia and hypomagnesemia should be corrected * Causes of hypovolemia: ⑴ paralytic ileus ⑵ vomiting ⑶ extensive exudation in abdominal cavity and peripancreatic region Ge nerous fluid resuscitation is very important * mild hyperglycemia: insulin treatment

4. Nutritional Support * fasting for a long time * persistent pain, ileus or the occurrence of a complication such as pseudocyst, phlegmon or abscess * enteral alimentation is better than that through the parenteral route

营养支持 非重症急性胰腺炎患者不需要空肠营养或静脉 营养,一般在病程的 4 天内即能进食。 重症急性胰腺炎病人应给予全胃肠外营养或肠 内营养。给予早期肠内营养。病程的第 3 或 4 天, 经内镜或在 X 线引导下给病人置入鼻空肠管, 并给予半量要素饮食。浓度大致为 J/ml , 如能耐受,逐渐增量至全能营养配方。

5. Antibiotics * prophylaxis * prevent intestinal bacteria translocation * Treat suppurative 化脓性的 complication

预防性使用抗生素 并发感染仍然是重症急性胰腺炎死亡的重要原因,因 此,有胰腺坏死存在就应考虑预防感染。 抗生素的选择应考虑其抗菌谱与感染病原菌的配对并 能有效穿透至胰腺实质中。 环丙沙星能透入胰腺坏死组织,甲硝唑虽分子量小、 通透性高,但只透入坏死液体,因此两者合用为宜胰 腺坏死者。 对于确有推荐使用亚胺培南(泰能) 500 mg , 3/ 日, 共 2 周。 其余抗生素均不能进入胰腺坏死组织,故而无效。

6. Analgesia * Meperidine ( 哌替啶, 度冷丁 ) is the preferred drug; * Morphine ( 吗啡 ) should be avoided: causing spasm of the sphincter of oddi

7.Pancreatic Exocrine Secretion Suppression 1.nasogastric suction 2.histamine(H2)-receptor antagonists 3.antacids 4.anticholinergics 5.glucagon 6.somatostatin, octreotide and sandostatin 生长抑素 施他宁 (250  g 静推, 3000  g 静滴 24h) 善宁 (0.1mg 静推, 0.6mg 静滴 24h) 7.proglumide (cck-receptor antagonists 7.Pancreatic Exocrine Secretion Suppression 1.nasogastric suction 2.histamine(H2)-receptor antagonists 3.antacids 4.anticholinergics 5.glucagon 6.somatostatin, octreotide and sandostatin 生长抑素 施他宁 (250  g 静推, 3000  g 静滴 24h) 善宁 (0.1mg 静推, 0.6mg 静滴 24h) 7.proglumide (cck-receptor antagonists)

8. Pancreatic enzyme inhibitor * aprotinin * gabexate * camostat

Surgical Treatment

Operative indication 1. secondary pancreatic infection 2. correction of associated biliary tract disease 3. progressive clinical deterioration S urgery is contraindicated in uncomplicated acute pancreatitis.

Surgical Procedure 1. peritoneal lavage: remove toxins and various metabolites 2. pancreatic drainage 3. debridement of necrotic tissue 4. biliary procedure: endoscopic sphincterotomy cholecystectomy remove the CBD stone

Complications Systemic complications ARDS Renal failure Cardiovascular failure MOSF Local complications pancreatic abscess pancreatic psuedocysts pancreatic phlegmon pancreatic ascites pleural effusion pancreatic fistula intestinal fistula

Thanks for Your Attention